Commiphora myrrh Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats

Lebda, Mohamed A.; Mostafa, Rabab E.; Taha, Nabil M.; El-Maksoud, Eman M. Abd; Tohamy, Hossam G.; Jaouni, Soad K. Al; El‐Far, Ali H.; Elfeky, Mohamed

doi:10.3390/antiox10111836

Cited by 20 publications

(8 citation statements)

References 53 publications

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“…Therefore, it can be a perfect antioxidant and ROS scavenger. Our findings are in agreement with other research that proved the cytoprotective effect of myrrh via free radical removal and stimulation of antioxidant activities in various organs, such as the heart and stomach (Abdel-Daim et al, 2015;Lebda et al, 2021). The high level of uric acid after cotreatment with AME in the current study could reflect its effective role in the attenuation of oxidative stress.…”

Section: O N L I N E F I R S T a R T I C L Esupporting

confidence: 93%

“…These health-enhancing pharmacological substances give myrrh several curative features, such as antioxidant, anticancer, antimicrobial, anti-inflammatory, and immunostimulant properties (Alqahtani et al, 2020). In addition, several studies on rats have revealed that myrrh could even promote the synthesis of cellular antioxidant potential, which results in a reduction in toxicity symptoms in some soft organs, such as the liver and stomach (Lebda et al, 2021;Alahmari et al, 2022). Myrrh appears to have significant economic and ecological value based on the above characteristics, and it may be able to be applied in the management of oxidative stress and inflammation-related conditions and toxicities.…”

Section: O N L I N E F I R S T a R T I C L Ementioning

confidence: 99%

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Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Ilyas,

Riaz,

Rasheed

et al. 2024

PJZ

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The kidney is one of the target organs whose structure and functions are significantly influenced by toxins. Because the protective impact of myrrh resin on renal damage induced by alcohol intake has not been previously evaluated, this study was designed to investigate the in vivo antioxidant activity of aqueous myrrh extract (AME) on oxidative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague-Dawley rats orally received 40% ethanol (3 g kg -1 ) and were then orally treated with (500 mg kg -1 ) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, urea, and uric acid levels along with histological changes, including shrunken glomeruli, necrosis, inflammatory cell infiltration, congestion, and edema. They also exhibited significantly elevated lipid peroxidation and oxidant radicals with decreased antioxidant parameters in renal tissue. In contrast, AME alone did not cause renal injury, and it was able to notably improve the toxic impacts of ethanol in the kidney when administered together. In conclusion, AME provided preservation against ethanol toxicity by scavenging reactive oxygen species (ROS) and relieving oxidative stress as a result of its rich chemical content of furano-sesquiterpenes, which possess powerful antioxidant activities.

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Section: O N L I N E F I R S T a R T I C L Esupporting

confidence: 93%

Section: O N L I N E F I R S T a R T I C L Ementioning

confidence: 99%

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Ilyas,

Riaz,

Rasheed

et al. 2024

PJZ

View full text Add to dashboard Cite

show abstract

“…Nizatidine is a histamine receptor antagonist that can be used in the treatment of allergic disease [20]. Nizatidine, tetradecanamine N,N-dimethyl, and N-methyl-N benzyltetradecanamine are bioactive compounds that are found in several medicinal plants, such as Citrullus colocynthis and Commiphora myrrh [21,22].…”

Section: Discussionmentioning

confidence: 99%

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

et al. 2022

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Heavy metals intoxication causes several health problems that necessitate finding new protective and therapeutic approaches. This study aimed to evaluate the impact of Musa sp. leaves extract (MLE) on hepato-renal toxicities induced by cadmium (Cd) in male mice. The phytochemical screening, metal chelating activity (MCA), and the median lethal dose (LD50) of MLE were determined. Fifty CD-1 male mice were used and intraperitoneally (i.p.) injected with MLE (1000 to 5000 mg/kg b.wt) for MLE LD50 determination. Another 50 mice were used for evaluating the effect of MLE on Cd toxicity. Blood samples were collected for hematological, liver, and kidney functions assessments. Liver tissue homogenates were used for determination of oxidant/antioxidant parameters. Liver and kidney tissues were harvested for histopathological and molecular investigations. MLE showed potent in vitro antioxidant activities. The MCA and LD50 of the MLE were 75 µg/mL and 3000 mg/kg b.wt, respectively. MLE showed beneficial therapeutic activity against hepato-renal toxicities in Cd-intoxicated mice, evidenced by improving the hematological, biochemical, histopathological, and molecular alterations.

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“…Among them, enzymes exist widely in eukaryotes and play an irreplaceable role in defending various tissues and organs against oxidative damage. For instance, GSH can scour free radicals and protect cell membrane and functional integrity; SOD protects the body by scavenging O2- and its level mainly reflects the body’s ability to scavenge oxygen free radicals; MDA mainly reflects the degree of lipid peroxidation in the body [ 42 , 43 , 44 ]. In this work, the activity of GSH and CAT notably down-regulated and the content of MDA clearly increased under cold exposure conditions.…”

Section: Discussionmentioning

confidence: 99%

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway

et al. 2022

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The body needs to generate heat to ensure basic life activities when exposed to cold temperatures. The liver, as the largest glycogen storage organ in the body and main heat-producing organ at rest, may play a role in chronic cold exposure. Recent studies suggested that pyroptosis plays a crucial role in liver diseases. However, the role of pyroptosis in cold stress-induced liver injury is not clear. Hence, in this study, we attempted to investigate the effects of chronic cold exposure on liver function, apoptosis, oxidative stress and inflammation in mice by establishing a mouse model of chronic cold exposure, and to investigate whether pyroptosis pathways are involved in the process of chronic cold exposure. In vivo, our results show that inflammatory cell infiltration and other pathological changes in liver cells and the activity of liver enzyme evidently increased in the serum and liver of cold-exposed mice, suggesting cold stress may result in liver injury. Remarkably, increased expression of heat shock protein 70 (HSP70) and HSP90 proteins proved the cold stress model is successfully constructed. Then, elevated levels of apoptosis, inflammation, oxidative stress and pyroptosis related proteins and mRNAs, such as cysteinyl aspartate specific proteinase-3 (Caspase-3), inducible nitric oxide synthase (iNOS), nuclear factor erythroid2-related factor 2 (Nrf2) and gasdermins D (GSDMD), confirmed that cold exposure activated apoptosis, oxidative stress and pyroptosis, and released inflammation cytokines. Meanwhile, in vitro, we got similar results as in vivo. Further, adding an NLR family pyrin domain containing 3 (NLRP3) inhibitors found that suppression expression of NLRP3 results in the essential proteins of pyroptosis and antioxidant evidently reduced, and adding GSDMD inhibitor found that suppression expression of GSDMD accompanies with the level of Nrf2 and heme oxygenase-1 (HO-1) obviously reduced. In summary, these findings provide a new understanding of the underlying mechanisms of the cold stress response, which can inform the development of new strategies to combat the effects of hypothermia.

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Commiphora myrrh Supplementation Protects and Cures Ethanol-Induced Oxidative Alterations of Gastric Ulceration in Rats

Cited by 20 publications

References 53 publications

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway

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