Annotation. Despite the prevalence of seborrheic dermatitis (SD), especially among young people, little is known about its clinical and anamnestic features in the population of Ukraine. To fill this gap, it is necessary to conduct a study of reliable data obtained from the domestic sample of working age. The aim of the study is to find the clinical and anamnestic features of men and women with generalized fatty form of seborrheic dermatitis of varying severity. A survey of 40 men and 40 young women (25-44 years according to the age periodization of the WHO, 2015) in patients with generalized fatty seborrheic dermatitis was conducted on the basis of the Department of Skin and Venereal Diseases with a postgraduate course in National Pirogov Memorial Medical University, Vinnytsya and the Military Medical Clinical Center of the Central Region. Retrospective analysis included assessment of passport, anamnestic, clinical data. Diagnosis of SD was established on the basis of complaints of the subject, life history and illness, examination of the face, scalp, torso and extremities with the assessment of subjective and objective signs of the disease. Statistical analysis was performed using the license package “Statistica 6.0”. It was found that the severity of SD increased with increasing length of service and depended on the type of professional activity. Stress, temperature, humidity, smoking, heredity caused the manifestation or exacerbation of dermatosis. Acne and rosacea often accompanied severe SD. Itching and oiliness of the skin, rash on the head and face, erythematous spots and plaques, the predominance of red dermographism were observed in both types of flow, and the feeling of dirt, localization of pathological elements on the body, sebaceous scales – only in severe. Thus, the data obtained in our study can form the basis for the development of an algorithm for monitoring patients with generalized seborrheic dermatitis of varying severity.