Common and critical inflammatory dermatoses every pathologist should know

Billings, Steven D.

doi:10.1038/s41379-019-0400-z

Cited by 8 publications

(5 citation statements)

References 81 publications

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“…In the recent dermatopathologic view, LSC is inflammatory dermatoses [9], but the mechanism of inflammation is not clear. So far, some gynecological diseases have been found associated with gut microbiota or vaginal microbiota dysbiosis.…”

Section: Discussionmentioning

confidence: 99%

Vaginal Microbiota Changes in the Vulvar Lichen Simplex Chronicus

Ma¹,

Wei²,

Chen³

et al. 2023

Clin. Exp. Obstet. Gynecol.

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Background:The vulvar lichen simplex chronicus (VLSC) is a common condition in gynecologic clinics. Though VLSC is not lifethreatening, it usually causes pruritus, soreness and dispareunia, which cause general discomfort. The exact etiology of VLSC is unclear. This study was performed to explore the vaginal microbiota of VLSC and to identify the possible microbial factors in attacks. Methods: Ninety women were recruited. 45 patients with VLSC and 45 women without vulvar symptom were identified as lichen simplex chronicus (LSC) and H groups respectively. The vaginal microbiota of the two arms were compared by the V3-V4 region of 16S rRNA sequencing. Results:The LSC group had less alpha diversity than H group (p < 0.05) and the beta diversity of LSC group was also distinct from the H group. Linear discriminant analysis effect size (LEfSE) analysis indicated that genus Sneathia and family Leptotrichiaceae were discriminant taxa in LSC group. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis found that microbial genes related to the signal transduction, metabolism of terpenoids and polyketides, transporters, nervous system, energy metabolism and others were different in the LSC and H groups. Conclusions: VLSC was associated with dysbioss of vaginal microbiota profiles compared with healthy control cases.

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Section: Discussionmentioning

confidence: 99%

Vaginal Microbiota Changes in the Vulvar Lichen Simplex Chronicus

Ma¹,

Wei²,

Chen³

et al. 2023

Clin. Exp. Obstet. Gynecol.

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“…These subtypes may coexist, but in general, the classical form is the most common, with pain being one of the main symptoms in this case 7 . Although they may occur spontaneously, more than 50% of lesions develop due to skin hyperactivity at trauma sites, with special emphasis on PPG, i.e., in these cases (30%), the pathergy phenomenon is essential 6,7 . In PPG, after a period of typical appearance (between four and six weeks), the surgical wound shows small dehiscence that usually coalesce into large ulceration areas in a process that goes beyond the surgical wound.…”

Section: Discussionmentioning

confidence: 99%

“…Although they may occur spontaneously, more than 50% of lesions develop due to skin hyperactivity at trauma sites, with special emphasis on postoperative ones (PPG) 6,7 . Multiple case reports have described the progress of PG after cosmetic, oncologic, and reconstructive breast surgery, but few PG reports address breast cancer after conservative surgery associated with radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer and pyoderma gangrenosum: a complication after conservative surgery and radiotherapy

Kuroda

Urban

Mendes³

et al. 2020

Mastology

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Pyoderma gangrenosum (PG) is a rare, ulcerative, and painful neutrophilic dermatosis of unknown cause associated with systemic diseases and/or pathergy phenomenon in 30% of cases. We report the case of a breast cancer patient submitted to oncoplastic conservative surgery followed by adjuvant radiotherapy, with long-term progression to PG. It’s rare and challeng ing nature reinforces the need for early diagnosis to increase treatment effectiveness and reduce morbidity.

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“…The endocannabinoid system includes the cannabinoid receptors, their endogenous ligands (endocannabinoids), and cannabinoid synthesizing and metabolizing enzymes [9]. Cannabinoid receptor 1 (CB1), to which the psychotropic effects of 9-tetrahydrocannabinol (9-THC) have been attributed, is expressed mainly in the central nervous system [10][11][12][13][14]. In contrast, cannabinoid receptor 2 (CB2) is expressed primarily by immune cells and has been found to play a key immunomodulatory role in various physiological and pathophysiological conditions [10][11][12][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity

Gaffal

Kemter

Scheu

et al. 2020

IJMS

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Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role in the sensitization phase of CHS by initiating T cell responses to topically applied haptens. The cannabinoid receptors 1 (CB1) and 2 (CB2) modulate DC functions and inflammatory skin responses, but their influence on the capacity of haptenized DCs to induce CHS is still unknown. We found lower CHS responses to 2,4-dinitro-1-fluorobenzene (DNFB) in wild type (WT) mice after adoptive transfer of haptenized Cnr2−/− and Cnr1−/−/Cnr2−/− bone marrow (BM) DCs as compared to transfer of WT DCs. In contrast, induction of CHS was not affected in WT recipients after transfer of Cnr1−/− DCs. In vitro stimulated Cnr2−/− DCs showed lower CCR7 and CXCR4 expression when compared to WT cells, while in vitro migration towards the chemokine ligands was not affected by CB2. Upregulation of MHC class II and co-stimulatory molecules was also reduced in Cnr2−/− DCs. This study demonstrates that CB2 modulates the maturation phenotype of DCs but not their chemotactic capacities in vitro. These findings and the fact that CHS responses mediated by Cnr2−/− DCs are reduced suggest that CB2 is a promising target for the treatment of inflammatory skin conditions.

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Common and critical inflammatory dermatoses every pathologist should know

Cited by 8 publications

References 81 publications

Vaginal Microbiota Changes in the Vulvar Lichen Simplex Chronicus

Vaginal Microbiota Changes in the Vulvar Lichen Simplex Chronicus

Breast cancer and pyoderma gangrenosum: a complication after conservative surgery and radiotherapy

Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity

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