Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: A voxel-based meta-analysis of functional magnetic resonance imaging studies

Delvecchio, Giuseppe; Fossati, Philippe; Boyer, Patrice; Brambilla, Paolo; Falkai, Peter; Gruber, Oliver; Hietala, Jarmo; Lawrie, Stephen M.; Martinot, Jean Luc; McIntosh, Andrew M.; Meisenzahl, Eva; Frangou, Sophia

doi:10.1016/j.euroneuro.2011.07.003

Cited by 211 publications

(152 citation statements)

References 63 publications

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“…Volumetric changes in these regions have previously been reported in BD (Selvaraj et al, 2012) and have been associated with specific BD-related cognitive functions (Delvecchio et al, 2012). The widespread gray matter alterations may explain why patients with BD complicated by T2DM or metabolic syndrome display adverse clinical or treatment outcomes (Ruzickova et al, 2003;McIntyre et al, 2010).…”

Section: Discussionmentioning

confidence: 91%

Insulin Resistance, Diabetes Mellitus, and Brain Structure in Bipolar Disorders

Hájek

Calkin

Blagdon

et al. 2014

Neuropsychopharmacol

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Type 2 diabetes mellitus (T2DM) damages the brain, especially the hippocampus, and frequently co-occurs with bipolar disorders (BD). Reduced hippocampal volumes are found only in some studies of BD subjects and may thus be secondary to the presence of certain clinical variables. Studying BD patients with abnormal glucose metabolism could help identify preventable risk factors for hippocampal atrophy in BD. We compared brain structure using optimized voxel-based morphometry of 1.5T MRI scans in 33 BD subjects with impaired glucose metabolism (19 with insulin resistance/glucose intolerance (IR/GI), 14 with T2DM), 15 euglycemic BD participants and 11 euglycemic, nonpsychiatric controls. The group of BD patients with IR, GI or T2DM had significantly smaller hippocampal volumes than the euglycemic BD participants (corrected p ¼ 0.02) or euglycemic, nonpsychiatric controls (corrected p ¼ 0.004). Already the BD subjects with IR/GI had smaller hippocampal volumes than euglycemic BD participants (t(32) ¼ À 3.15, p ¼ 0.004). Age was significantly more negatively associated with hippocampal volumes in BD subjects with IR/GI/T2DM than in the euglycemic BD participants (F(2, 44) ¼ 9.96, p ¼ 0.0003). The gray matter reductions in dysglycemic subjects extended to the cerebral cortex, including the insula. In conclusion, this is the first study demonstrating that T2DM or even prediabetes may be risk factors for smaller hippocampal and cortical volumes in BD. Abnormal glucose metabolism may accelerate the age-related decline in hippocampal volumes in BD. These findings raise the possibility that improving diabetes care among BD subjects and intervening already at the level of prediabetes could slow brain aging in BD.

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Section: Discussionmentioning

confidence: 91%

Insulin Resistance, Diabetes Mellitus, and Brain Structure in Bipolar Disorders

Hájek

Calkin

Blagdon

et al. 2014

Neuropsychopharmacol

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“…Interestingly, previous studies have suggested that an impaired response inhibition is the most likely candidate for a neurocognitive endophenotype for BD (62)(63)(64). However, contrary to the functional plasticity hypothesis, both children and adults with BD showed deficits in their ability to engage the right inferior frontal cortex during a variety of tasks (65)(66)(67).…”

Section: Discussionmentioning

confidence: 95%

Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus

Hájek

Cullis

Novák

et al. 2013

Biological Psychiatry

125

110

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“…A relatively well-examined paradigm in affective disorders is the measurement of neural reactions to emotional facial expressions. This paradigm has demonstrated a relatively consistent increased neural activity of subcortical, limbic brain regions (amygdala, parahippocampal formations, striatum) in combination with reduced activity of the lateral prefrontal cortex (Delvecchio et al, 2012). This pattern of findings is not specific for bipolar disorders but corresponds to the main finding of functional imaging studies of a broad spectrum of mood and anxiety disorders, including unipolar depression and anxiety disorder.…”

Section: Functional Imagingmentioning

confidence: 54%