Common and uncommon features of nephrogenic adenoma revisited

Santi, Raffaella; Angulo, Javier C.; Nesi, Gabriella; Petris, Giovanni De; Hes, Ondřej; López, José I.

doi:10.1016/j.prp.2019.152561

Cited by 10 publications

(18 citation statements)

References 30 publications

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Section: Nephrogenic Adenoma (Na)mentioning

confidence: 99%

“…The histological spectrum of nephrogenic adenomas is wide [17], with microcystic, cystic, papillary (Figure 1c), solid, and flat architectures, as well as clear cell, oncocytic, and fibro-myxoid changes. Pseudo-malignant features like muscle pseudo-invasion, nuclear atypia, and occasional GATA-3 positivity may occur [17]. Special attention should be paid to distinguish urothelial carcinomas mimicking nephrogenic adenomas, especially when NA present a pseudo-infiltrative growth pattern [1,17].…”

Section: Nephrogenic Adenoma (Na)mentioning

confidence: 99%

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Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Manini

Angulo

López

2021

Clinics and Practice

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A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract. This narrative collects most of them from a clinical and pathologic perspective, offering urologists and general pathologists their most salient definitory features. Together with classical, well-known, entities such as urothelial papillomas (conventional (UP) and inverted (IUP)), nephrogenic adenoma (NA), polypoid cystitis (PC), fibroepithelial polyp (FP), prostatic-type polyp (PP), verumontanum cyst (VC), xanthogranulomatous inflammation (XI), reactive changes secondary to BCG instillations (BCGitis), schistosomiasis (SC), keratinizing desquamative squamous metaplasia (KSM), post-radiation changes (PRC), vaginal-type metaplasia (VM), endocervicosis (EC)/endometriosis (EM) (müllerianosis), malakoplakia (MK), florid von Brunn nest proliferation (VB), cystitis/ureteritis cystica (CC), and glandularis (CG), among others, still other cellular proliferations with concerning histological features and poorly understood etiopathogenesis like IgG4-related disease (IGG4), PEComa (PEC), and pseudosarcomatous myofibroblastic proliferations (post-operative spindle cell nodule (POS), inflammatory myofibroblastic tumor (IMT)), are reviewed. Some of these diagnoses are problematic for urologists, other for pathologists, and still others for both. Interestingly, the right identification of their definitory features will allow their correct diagnoses, thus, avoiding overtreatment. The literature selected for this review also focuses on the immunohistochemical and/or molecular data useful to delineate prognosis.

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Section: Nephrogenic Adenoma (Na)mentioning

confidence: 99%

Section: Nephrogenic Adenoma (Na)mentioning

confidence: 99%

Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Manini

Angulo

López

2021

Clinics and Practice

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“…The bland cytologic features of this histologic subtype contrast with its frank infiltrative nature, even reaching the muscularis propria in some cases. Since nephrogenic adenoma may display also a concerning pseudo-infiltrative growth [28], an immunohistochemical study with PAX-8, CK7, p63, and napsin A [29] may be useful to make the differential diagnosis in problematic cases. The clinical significance of this histologic change is not established so far.…”

Section: Small Tubules and Nephrogenic Adenoma-like Architecturementioning

confidence: 99%

Unusual Faces of Bladder Cancer

Manini

López

2020

Cancers

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The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architecture and cytology. Thus, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.

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“…The histological spectrum of nephrogenic adenomas is wide [17], with microcystic, cystic, papillary (Figure 1c), solid, and flat architectures, as well as clear cell, oncocytic, and fibro-myxoid changes. Pseudo-malignant features like muscle pseudo-invasion, nuclear atypia and occasional GATA-3 positivity may occur [17]. Special attention should be paid to distinguish urothelial carcinomas mimicking nephrogenic adenomas, especially when NA present a pseudo-infiltrative growth pattern [1,17].…”

Section: Inverted Urothelial Papillomamentioning

confidence: 99%

“…Pseudo-malignant features like muscle pseudo-invasion, nuclear atypia and occasional GATA-3 positivity may occur [17]. Special attention should be paid to distinguish urothelial carcinomas mimicking nephrogenic adenomas, especially when NA present a pseudo-infiltrative growth pattern [1,17]. The combined expression of PAX-8 and absence of p63 and GATA-3 should solve difficult cases [16].…”

Section: Inverted Urothelial Papillomamentioning

confidence: 99%

Simulators of Urothelial Carcinoma

Manini¹,

Angulo²,

Ji³

2020

Preprint

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A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract. This narrative collects most of them from a clinical and pathologic perspective offering urologists and general pathologists their most salient definitory features. Together with classical, well-known, entities such as urothelial papillomas (conventional and inverted), nephrogenic adenoma, polypoid cystitis, fibroepithelial polyp, prostatic-type polyp, verumontanum cyst, xanthogranulomatous inflammation, reactive changes secondary to BCG instillations, schistosomiasis, keratinizing desquamative squamous metaplasia, post-radiation changes, vaginal-type metaplasia, endocervicosis/endometriosis (müllerianosis), malakoplakia, florid von Brunn nest proliferation, cystitis/ureteritis cystica and glandularis, among others, still other cellular proliferations with concerning histological features and poorly understood etiopathogenesis like IgG4-related disease, PEComa, and pseudosarcomatous myofibroblastic proliferations (post-operative spindle cell nodule, inflammatory myofibroblastic tumor), are reviewed. Some of these diagnoses are problematic for urologists, other for pathologists, and still others for both. Interestingly, the right identification of their definitory features will allow their correct diagnoses thus avoiding overtreatment. The literature selected for this review also focuses on the immunohistochemical and/or molecular data useful to delineate prognosis.

show abstract

Common and uncommon features of nephrogenic adenoma revisited

Cited by 10 publications

References 30 publications

Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis

Unusual Faces of Bladder Cancer

Simulators of Urothelial Carcinoma

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