Common anticholinergic solanaceaous plants of temperate Europe - A review of intoxications from the literature (1966–2018)

Fatur, Karsten; Kreft, Samo

doi:10.1016/j.toxicon.2020.02.005

Cited by 19 publications

(13 citation statements)

References 112 publications

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“…Intoxication in general is not uncommon, whereas intoxication specifically caused by lupini beans remains rare. 8,9 To our knowledge, 7 similar case reports have been published to date. 3,[10][11][12][13][14][15] In all of the cases, patients presented with manifestations of anticholinergic toxicity, but presenting symptoms varied among the publications.…”

Section: Discussionmentioning

confidence: 77%

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Acute Bilateral Fixed Mydriasis Caused by Lupini Bean Intoxication

Lahoud

Hanna

Jalkh³

et al. 2021

Wilderness & Environmental Medicine

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Lupini beans are legume seeds of the genus Lupinus, consumed in many parts of the world. The main species are Lupinus mutabilis, Lupius angustifolius, and Lupinus albus. The latter is commonly eaten as a snack in Mediterranean countries. The beans are very rich in alkaloids, which give them a bitter taste. One of these alkaloids was shown to cause anticholinergic effects. Lupini beans, if improperly prepared, can cause toxicity manifesting as an anticholinergic syndrome. We present the case of a 50-y-old woman who presented with bilateral mydriasis, mouth dryness, and anxiety. We confirmed that the patient consumed partially debittered lupini beans a few hours before presentation. The rest of her physical and ophthalmic examination results were within normal limits. Her symptoms resolved without therapy within 12 h from presentation and were attributed to ingestion of incorrectly prepared lupine seeds.

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Section: Discussionmentioning

confidence: 77%

“…Intoxication in general is not uncommon, whereas intoxication specifically caused by lupini beans remains rare. 8,9…”

Section: Discussionmentioning

confidence: 99%

Acute Bilateral Fixed Mydriasis Caused by Lupini Bean Intoxication

Lahoud

Hanna

Jalkh³

et al. 2021

Wilderness & Environmental Medicine

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“…It is worth noting that water infusions are the least common of the methods here presented to appear in the literature; few historical sources seem to note these plants being employed in this way and some even note that though medicinal, such usage is unwise [ 19 ]. One recent study [ 20 ] found the use of a plant that may have been Hyoscyamus niger as a medicinal tea, but the vast majority of usage as water infusions has centred on intentional intoxication [ 21 ]. These are mainly reported in toxicological studies as summarised in the previous reference, which is unsurprising given the dangerously large quantity of alkaloids that one could easily consume in this manner.…”

Section: Resultsmentioning

confidence: 99%

Pipes and Potions: Testing the Efficacy of European Folk Preparation Methods for Anticholinergic Solanaceae Plants

Fatur

Ravnikar

Fras

et al. 2022

Plants

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The present article sought to evaluate the efficiency of various folk preparation methods commonly used in Europe for employing anticholinergic Solanaceae plants. The study aimed to uncover which folk methods were effective for the extraction of the anticholinergic tropane alkaloids of these plants, atropine and scopolamine. The folk extractions that were tested sought to simulate the preparation of teas, cold-water infusions, unguents, tinctures, fortified wines, and smoking. All preparation types and a control were then put through an extraction process to see what amount of the alkaloids had been maintained. These extractions were then analysed using high-performance liquid chromatography (HPLC). Cold- and hot-water preparations, tinctures, and fortified wines all proved to be effective means of extracting atropine and scopolamine from plant material under conditions seen in folk usage. Smoking and the oil-based unguent, however, yielded no alkaloids, suggesting a lack of efficiency for these preparations, a problem with our methodology, or possible chemical changes and losses associated with the preparation procedure.

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“…Aerosol therapy has a long history as a method used for the administration of drugs (1)(2)(3). In ancient times aerosols were obtained mainly from plants rich in tropane alkaloids (such as hyoscyamine, atropine and scopolamine) (4)(5)(6)(7)(8). The first data came from Ayurvedic medicine about 4,000 years ago.…”

Section: The History Of Aerosol Therapy Usementioning

confidence: 99%

“…1500 B.C. ), papyrus scrolls containing a drawing presenting a patient inhaling vapours from incinerated Hyoscyamus niger (henbane) leaves were found in one of the Thebes pyramids (9)(10)(11)(12)(13). Anticholinergic properties of raw plant materials were described by the Indian physicians Charaka and Sushruta (approx.…”

Section: The History Of Aerosol Therapy Usementioning

confidence: 99%

The history, current state and perspectives of aerosol therapy

et al. 2021

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Nebulization is a very effective method of drug administration. This technique has been popular since ancient times when inhalation of plants rich in tropane alkaloids with spasmolytic and analgesic effects was widely used. Undoubtedly, the invention of anasthesia in the 19th century had an influence on the development of this technique. It resulted in the search for devices that facilitated anasthesia such as pulveriser or hydronium. From the second half of the 21st century, when the first DPI and MDI inhalers were launched, the constant development of aerosol therapy has been noticed. This is due to the fact that nebulization, compared with other means of medicinal substance application (such as oral and intravenous routes of administration), is safer and it exhibits a positive dose/efficacy ratio connected to the reduction of the dose. It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.

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Common anticholinergic solanaceaous plants of temperate Europe - A review of intoxications from the literature (1966–2018)

Cited by 19 publications

References 112 publications

Acute Bilateral Fixed Mydriasis Caused by Lupini Bean Intoxication

Acute Bilateral Fixed Mydriasis Caused by Lupini Bean Intoxication

Pipes and Potions: Testing the Efficacy of European Folk Preparation Methods for Anticholinergic Solanaceae Plants

The history, current state and perspectives of aerosol therapy

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