Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review

Murudkar, Prajakta H.; Tambe, Mukul S.; Chandrasekar, S.B.; Boddeda, Bhavani; Pawar, Anil T.

doi:10.3389/fphar.2022.991083

Cited by 5 publications

(2 citation statements)

References 61 publications

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“…The philosophical background of the alternative medicinal practice is based on Yinyangism and focuses on life energy, called Qi, and its flow along pathways through the body, called meridians [24]. Today, it is widely used as a complementary alternative medicine (CAM) approach and involves herbal and dietary treatment, moxibustion, acupuncture, acupressure, massage, exercise, and meditation [25]. Common polyherbal Chinese medications implicated in HILI include Gynura japonica (tusanqi), Ba Jiao Lian (Dysosma pleianthum), Bol Gol Zhee (Fructus psoraleae), Chi R Yun (Breynia officinalis), Jin Bu Huan (Lycopodium serratum), Ma Huang (Ephedra), Sho Saiko To, and Shou Wu Pian (Polygonum multiflorum) [11].…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

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Herbal-induced liver injury (HILI) continues to increase in prevalence each year due to the ongoing popularity of herbal supplements and complementary and alternative medicines. A detailed literature review of case reports and clinical studies published from March 2021 to March 2023 was performed. We discuss the epidemiology and diagnosis of HILI as well as the current and proposed laws and regulations. The 2021 ACG guidelines and 2022 AASLD practice guidelines for the diagnosis and management of drug and herbal-induced liver injury are discussed. We describe updates to previously reported etiologies of HILI such as ayurveda, ashwagandha, turmeric, kratom, green tea extract, and garcinia cambogia. Newly described supplements resulting in HILI, such as tinospora cordifolia, horse chestnut, alkaline water, and more, are described. We discuss newly and previously identified hepatoprotective herbal supplements as they have been reported in the study of animal models and human liver cells. This review suggests the need for ongoing research on the causes and mechanisms of HILI to ensure its proper diagnosis, prevention, and treatment in the future. The goal of this review is to provide novice and expert readers with knowledge regarding the possible etiologies of HILI and a general overview.

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Section: Traditional Chinese Medicinementioning

confidence: 99%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

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“…Preliminary oral LD50 (median lethal dose) doses of aqueous extract of Indian almond in rats were found to be above 3000mg/kg as gotten from an acute toxicity study [14]. Group C was treated with one-fifth of LD50 dose of aqueous extract (600mg/kg per day per oral) [15].…”

Section: Experimental Designmentioning

confidence: 99%

Effect of Aqueous Leaf Extract of Terminalia catappa (Indian Almond) on the Liver of Alloxan-Induced Diabetic Wistar Rat

Ero,

Osadolor,

Oyakhilome

2023

IJRSI

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Different schools of thought believed the Indian almond has antidiabetic and hepatoprotective potentials, however, there is paucity of information on the ability of this plant to carry out its antidiabetic properties. This study therefore seeks to determine the effect of aqueous leaf extract of Indian almond on the liver of alloxan-induced diabetic Wistar rats. Three groups of Wistar rats were used in this study, a normal control, a diabetic control, and a treated group (5 per group). Rats in the normal group were administered distilled water orally per day, rats in the diabetic group were intraperitoneally injected with 150mg/kg body weight of alloxan and administered distilled water orally per day, while rats in the treated group were intraperitoneally injected with 150mg/kg of alloxan and treated orally with 600mg/kg body weight of aqueous leaf extract of Indian almond per day for 21days. Administration of aqueous leaf extract of Indian almond to the diabetic rats caused a significant decrease in the level of blood glucose, activities of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP), total bilirubin and conjugated bilirubin (p< 0.05) and a significant increase in the level of total protein and albumin (p< 0.05) when compared with the control groups. The results obtained from this study suggested that the aqueous leaf extract of Indian almond possesses antidiabetic activity and could be used for the management of diabetes and liver damage associated with its metabolic consequences.

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Biochemical and In Silico Aspects of Active Compounds From Nyctanthes arbor‐tristis Flower As Antidiabetic Agent

ALNadhari,

Alsakkaf,

Albarakat

2024

Biotech and App Biochem

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Targeting alpha‐glucosidase (maltase‐glucoamylase [MGAM] and sucrase‐isomaltase [SI]) under diabetes conditions is important to overcome hyperglycemia. Moreover, it is necessary to mitigate hyperglycemia‐mediated oxidative stress to evade the progression of diabetes‐associated secondary complications. Hence, in the present study, under‐explored Nyctanthes arbor‐tristis flowers (NAFs) were studied for inhibition of alpha‐glucosidase activities. The NAF methanolic extract (NAFME) was prepared. Through liquid chromatography/electrospray ionization tandem mass spectrometry (LC–ESI/MS/MS) analysis, various phytocompounds belonging to different classes—flavonoids, iridoid glycosides, proanthocyanidin, anthocyanin, polyphenol, phenolic acid, fatty acid ester, and carotenoid—were identified. NAFME showed in vitro antioxidant activity. NAFME inhibited maltase, sucrase, glucoamylase, and isomaltase in mixed mode with Ki values of 179.93, 176.38, 126.03, and 201.56 µg/mL, respectively. In silico screening of phytocompounds identified in NAFME indicated that hinokiflavone (HKF), pelargonidin‐3‐O‐glucoside (PG), isorhamnetin‐3‐glucoside‐7‐rhamnoside (IGR), and petunidin‐3‐rutinoside (PR) showed better interactions with different subunits of human alpha‐glucosidase, namely, N‐terminal (Nt‐MGAM and Nt‐SI) and C‐terminal (Ct‐MGAM and Ct‐SI). Molecular dynamics (MD) simulation, binding free energy study (molecular mechanics–generalized Born surface area [MM/GBSA]), and post‐MD simulation studies (principal component analysis [PCA] and dynamic cross‐correlation matrix [DCCM]) provided an in‐depth understanding of these ligands’ interactions with proteins. The overall efficacy of NAFME against oxidative stress and alpha‐glucosidase in vitro is understood. Moreover, in silico analysis has shown the possible potential of HKF, PG, IGR, and PR to act as alpha‐glucosidase inhibitors. Further studies on the antidiabetic potential of NAFME, HKF, PG, IGR, and PR in in vivo conditions are required to fully unveil the applicability of NAFME in the management of T2DM as a complementary medicine.

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Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review

Cited by 5 publications

References 61 publications

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Effect of Aqueous Leaf Extract of Terminalia catappa (Indian Almond) on the Liver of Alloxan-Induced Diabetic Wistar Rat

Biochemical and In Silico Aspects of Active Compounds From Nyctanthes arbor‐tristis Flower As Antidiabetic Agent

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