Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment

Galli, Luisa; Venturini, Elisabetta; Bassi, Andrea; Gattinara, Guido Castelli; Chiappini, Elena; Defilippi, Claudio; Diociaiuti, Andrea; Esposito, Susanna; Garazzino, Silvia; Giannattasio, Antonietta; Krzysztofiak, Andrzej; Latorre, S.; Vecchio, Andrea Lo; Marchisio, Paola; Montagnani, Carlotta; Nicolini, Giangiacomo; Novelli, Andréa; Rossolini, Gian María; Tersigni, Chiara; Villani, Alberto; Hachem, May El; Neri, Iria

doi:10.1016/j.clinthera.2019.01.010

Cited by 43 publications

(41 citation statements)

References 77 publications

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“…We do not know if this observation can be generalized to other Italian regions, but this observation should represent a warning. In spite of the signi cantly higher proportion of strains resistant to cotrimoxazole in outpatients (8% vs. 4.1%), as already described 9 , in our study resistance to cotrimoxazole was lower than the 10% threshold proposed for other drugs to be used for rst line therapy of skin lesions 8 and therefore it could represent an acceptable rst choice, pending susceptibility tests. The generally lower proportion of resistant strains in inpatients could seem a paradox.…”

Section: Discussioncontrasting

confidence: 48%

“…A recent Italian consensus on the treatment of skin infections in pediatrics 8 indicated clindamycin for rst line treatment in communities where proportions of MRSA is > 10% if clindamycin resistance is < 10%. Considering our epidemiology clindamycin (11% in out-and 14% in inpatients resistant strains) did not meet these criteria and could not represent a possible choice for empirical therapy before susceptibility tests availability.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Susceptibility of Staphylococcus Aureus Isolated from Skin Lesions in Children. A Retrospective Analysis from a Tertiary Care Italian Pediatric Hospital

Lezzi

Bandettini

Ugolotti

et al. 2020

Preprint

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Background: knowledge on antibiotic susceptibility of S.aureus strains isolated from skin lesions in pediatric Italian patients is limited.Methods: retrospective analysis of antibiotic susceptibility of S.aureus strains isolated from skin infections observed from January 2013 to June 2019 at the IRCCS Istituto Giannina Gaslini, Genoa – ItalyResults: a total of 1833 strains were analyzed. Methicillin resistance was more frequent in cultures from outpatients than from inpatients (18% vs. 14%, p=0.04) as well as resistance to cotrimoxazole (8% vs. 4.1%, p<0.001) Resistance to ampicillin was 99% in both groups, while to clindamycin it was 11% and 14%, respectively. Among topical antibiotics fusidic acid showed the better resistance profile (3%).Conclusions: the proportion of antibiotic resistance in S.aureus skin infections in Italian children is not negligible. This could represent a problem, especially for orally administered drugs.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility of Staphylococcus Aureus Isolated from Skin Lesions in Children. A Retrospective Analysis from a Tertiary Care Italian Pediatric Hospital

Lezzi

Bandettini

Ugolotti

et al. 2020

Preprint

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“…In pediatric patients suffering from NS, barrier skin defect and immune dysregulation lead to recurrent cutaneous infections, including severe ones up to sepsis. Thus, prompt treatment, including the appropriate antimicrobial agent, is of critical importance to control these events ( 84 ).…”

Section: Resultsmentioning

confidence: 99%

Netherton Syndrome in Children: Management and Future Perspectives

et al. 2021

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Netherton syndrome (NS) is a genetic, multisystemic disease classically distinguished by a triad of clinical manifestations: congenital ichthyosiform erythroderma, hair shaft abnormalities, and immune dysregulation. Due to the complex pathogenesis of the disease, there are no specific therapies currently accessible for patients with NS. An early diagnosis is crucial to start the correct management of these patients. A multidisciplinary approach, including specialists in immunology, allergology, and dermatology, is necessary to set up the best therapeutic pathway. We conducted a review with the aim to summarize the different therapeutic strategies currently accessible and potentially available in the future for children with NS. However, given the limited data in the literature, the best-tailored management should be decided upon the basis of the specific clinical characteristics of the patients with this rare clinical condition. Further comprehension of the pathophysiology of the disease could lead to more efficacious specific therapeutic options, which could allow a change in the natural history of NS.

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“…The most effective topical antibiotics for impetigo include mupirocin, fusidic acid, and retapamulin, with a resistance rate of <1%. 12 However, for mupirocin, the REDUCE-MRSA (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate MRSA) trial reported a higher resistance rate of 7.5% among 3173 MRSA isolates. 13 For MRSA-associated impetigo, systemic treatment is recommended.…”

Section: Discussionmentioning

confidence: 99%

“…In cases of suspected MRSA, TMP-SMX, daptomycin, and ceftaroline are equally effective and safe alternatives. 12 , 14 …”

Section: Discussionmentioning

confidence: 99%

Bilateral Endogenous Methicillin-Resistant <i>Staphylococcus aureus</i> Endophthalmitis in a Young Athlete: A Story of Full Recovery

Corredores¹,

Halpert²,

Cohen³

et al. 2021

tjo

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Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment

Cited by 43 publications

References 77 publications

Antibiotic Susceptibility of Staphylococcus Aureus Isolated from Skin Lesions in Children. A Retrospective Analysis from a Tertiary Care Italian Pediatric Hospital

Antibiotic Susceptibility of Staphylococcus Aureus Isolated from Skin Lesions in Children. A Retrospective Analysis from a Tertiary Care Italian Pediatric Hospital

Netherton Syndrome in Children: Management and Future Perspectives

Bilateral Endogenous Methicillin-Resistant <i>Staphylococcus aureus</i> Endophthalmitis in a Young Athlete: A Story of Full Recovery

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