Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff, Ronald N.; Briggs, Michael B.; Kanduc, Darja; Shores, Darla R.; Kovatsi, Leda; Vardavas, Alexander; Porter, Alan L.

doi:10.1016/j.toxrep.2021.08.007

Cited by 8 publications

(9 citation statements)

References 185 publications

(206 reference statements)

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“…U.S. dietary consumption activates the innate immune system and impairs adaptive immunity, leading to chronic inflammation and an impaired host defense against viruses [ 77 ]. The common contributing factors of chronic inflammation were suggested in COVID-19 and inflammatory bowel disease [ 80 ]. Obese persons are vulnerable to COVID-19 because obesity-induced expansion of adipocytes alters the function and architecture of adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Influence of Nutritional Intakes in Japan and the United States on COVID-19 Infection

Kagawa

2022

Nutrients

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The U.S. and Japan are both democratic industrialized societies, but the numbers of COVID-19 cases and deaths per million people in the U.S. (including Japanese Americans) are 12.1-times and 17.4-times higher, respectively, than those in Japan. The aim of this study was to investigate the effects of diet on preventing COVID-19 infection. An analysis of dietary intake and the prevalence of obesity in the populations of both countries was performed, and their effects on COVID-19 infection were examined. Approximately 1.5-times more saturated fat and less eicosapentaenoic acid/docosahexaenoic acid are consumed in the U.S. than in Japan. Compared with food intakes in Japan (100%), those in the U.S. were as follows: beef 396%, sugar and sweeteners 235%, fish 44.3%, rice 11.5%, soybeans 0.5%, and tea 54.7%. The last four of these foods contain functional substances that prevent COVID-19. The prevalence of obesity is 7.4- and 10-times greater in the U.S. than in Japan for males and females, respectively. Mendelian randomization established a causal relationship between obesity and COVID-19 infection. Large differences in nutrient intakes and the prevalence of obesity, but not racial differences, may be partly responsible for differences in the incidence and mortality of COVID-19 between the U.S. and Japan.

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Section: Discussionmentioning

confidence: 99%

Influence of Nutritional Intakes in Japan and the United States on COVID-19 Infection

Kagawa

2022

Nutrients

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“…2 .). The present approach is similar to the dot-product approach used in the IBD and GIC studies ( Kostoff et al, 2021 , 2022 ). A core literature query was defined for COVID-19, applied to PubMed, and the resultant retrieval (∼146,000 records with abstracts, covering 1/2020-11/2021) was imported into VantagePoint (VP) software ( www.theVantagePoint.com ).…”

Section: Methodsmentioning

confidence: 99%

“…The central component of our approach is identification and elimination of CFs to these myriad chronic diseases, although complementary treatments can be used for the disease reversal process when necessary. Our group also published two papers ( Kostoff et al, 2021 , 2022 ) showing the commonality of CFs that impact infectious and chronic diseases (COVID-19 and Inflammatory Bowel Disease (IBD) in the first study ( Kostoff et al, 2021 ), and COVID-19 and Gastrointestinal Cancer (GIC) in the second study ( Kostoff et al, 2022 )). The results of these two studies imply that our toxicology-based approach for preventing and reversing chronic diseases can be integrated successfully with the present virology-based approach to preventing and reversing communicable diseases (that exploit immune system dysfunction), such as COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“…Our purpose in the present paper is twofold: 1) show the increasing breadth of CFs that adversely impact COVID-19 directly, and 2) show some of the mechanisms through which this impact is enabled. For the key components of COVID-19 and toxicology, the COVID-19 background can be found in the IBD paper ( Kostoff et al, 2021 ), and the toxicology background can be found in the GIC paper ( Kostoff et al, 2022 ). Both will be summarized briefly here.…”

Section: Introductionmentioning

confidence: 99%

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Modifiable contributing factors to COVID-19: A comprehensive review

Kostoff

Briggs²,

Kanduc

et al. 2023

Food and Chemical Toxicology

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“…Further, our recent studies on common CFs between COVID-19 and selected chronic diseases 5,6 show that many of the CFs that enable or exacerbate COVID-19 also enable or exacerbate the selected chronic diseases studied (Inflammatory Bowel Disease, IBD; Gastrointestinal Cancer, GIC). Thus, while additional studies are required for a more complete picture, it appears that the methods we have developed for preventing or reversing chronic diseases may also be applicable to preventing infectious diseases.…”

Section: Introductionmentioning

confidence: 99%