“…2(c 58 , R, python 59 , C++ 60,61 , C# 62 , Java 63 and perl 64 , Igor Pro, etc. ; and finally (i) compatible with cloud and high-performance computing by supporting parallel read and write 65 Among the many file formats we tested including MathWorks' .MAT files 58 , XML 66 OME-TIFF files 52 , home-made binary files, common data format (CDF) 67 , net common data format (NetCDF) 68 , hierarchical data format (HDF5) 69 , Zarr 70 , etc., HDF5 was the only file format that satisfied all our requirements. In fact, HDF5 supports most popular data models such as NetCDF, NeXus 48 , Coherent X-Ray Imaging (CXI) data 71 , DREAM.3D model 55 Traceability and reproducibility of the experiments as well as the data processing routines in h5USID are captured through comprehensive and consistent metadata stored as attributes, in addition to links created between the data source and the analysis results within the HDF5 file.…”