Common echocardiography findings in pretransplant dialysis patients and their associations

Pakfetrat, Maryam; Roozbeh, Jamshid; Nikoo, Mohammad Hossein; Asem, Zahra; Malekmakan, Leila; Nikoo, Mohammad Ali

doi:10.1016/j.hkjn.2013.07.001

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…The finding that anemia was independently associated with LV diastolic dysfunction is similar to the study by Pakfetrat et al, which reported a negative correlation between hemoglobin levels and presence of LV diastolic dysfunction in patients with CKD. 32 Anemia is a known associating factor in heart failure, and in a recent study by Makubi et al, anemia was independently associated with heart failure in a cohort of heart failure patients attending care and treatment at MNH, linking the association between anemia and presence of LV dysfunction. 33 The prevalence of clinical heart failure in this study was 27.7%.…”

Section: Discussionmentioning

confidence: 95%

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study

Chillo¹,

Mujuni²

2018

RRCC

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Purpose: Chronic kidney disease (CKD) is prevalent in sub-Saharan Africa and is a significant cause of mortality, which may result from kidney failure or congestive heart failure-a frequent complication of CKD. There is however scarcity of documented literature on the magnitude and associated factors of echocardiographically determined left ventricular (LV) dysfunction among CKD patients in Tanzania. Patients and methods: A prospective cross-sectional study was conducted from May 2014 to January 2015 at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania. Patients ≥18 years with CKD were consecutively enrolled. Clinical characteristics, cardiovascular risk profiles, and laboratory findings including serum creatinine, urea, hemoglobin, and cholesterol levels were collected. Echocardiography was performed to assess LV function using standard criteria. Results: One hundred and ninety-one CKD patients fulfilled the inclusion criteria. The mean ± SD age was 48 ± 13 years, and 54.5% were men. A total of 98.4% of the patients were hypertensive, and diabetes was present in 22.8% while 97.9% had end-stage renal disease. The prevalence of LV systolic and diastolic dysfunction was 16.2% and 68.6%, respectively. A clinical finding of heart failure was the only independent predictor of LV systolic dysfunction (odds ratio [OR] = 2.9, p = 0.012), while independent predictors of LV diastolic dysfunction were anemia (OR = 4.9, p = 0.01), severe hypertension (OR = 9.2, p = 0.001), and female gender (OR = 1.7, p = 0.002). Conclusion: LV dysfunction is prevalent among CKD patients seen at MNH and is associated with clinical heart failure, anemia, severe hypertension, and female gender. Echocardiography should be performed in patients with CKD to detect overt or subclinical LV dysfunction.

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Section: Discussionmentioning

confidence: 95%

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study

Chillo¹,

Mujuni²

2018

RRCC

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“…Pakfetrat et al showed in a previous study 6 evaluating 1354 ESRD patients from 2000 to 2010; LVH was the most prevalent echocardiography finding (47.5%) and atrial dilation, diastolic dysfunction, dilated end diastolic dimension were followed next, and systolic dysfunction was the least prevalent (18.5%). Older age, male gender, longer duration of hemodialysis and anemia correlated with echocardiographic abnormalities and hypocalcemia was associated with atrial and LV End diastolic dilation.…”

Section: Discussionmentioning

confidence: 96%

“…Tissue Doppler imaging is a method for accurate estimation of myocardial systolic function, diastolic velocities and deformation information which is independent on volume load and is a good tool for precise assessment of LV function before systolic and diastolic dysfunction by conventional echocardiography appears. 6 , 7 There is evidence of tissue Doppler imaging changes after renal transplantations that could measure systolic and diastolic function at subclinical stages and showed improvement of LV function post-transplant. 8 - 11 …”

Section: Introductionmentioning

confidence: 99%

The effect of kidney transplantation on speckled tracking echocardiography findings in patients on hemodialysis

Hamidi¹,

Kojuri²,

Attar³

et al. 2018

J Cardiovasc Thorac Res

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Introduction: Cardiac dysfunction is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Previous studies have shown that kidney transplantation can reverse some of the gross changes in the myocardial structure such as left ventricular ejection fraction (LVEF) and volumes. Whether kidney transplantation can reverse the subtle and early myocardial changes in ESRD patients who do not suffer from gross alternations in myocardial function is not yet studied. The aim of this study was to answer this question. Methods: We followed 25 patients with ESRD at baseline that all of them had a kidney transplant and were reassessed 1 month after the transplantation. Conventional and speckle tracking echocardiography (STE)was done at baseline and 1 month after kidney transplantation in patients. Results: LV hypertrophy was the most prevalent finding at baseline (58%), followed by diastolic dysfunction (53%). Kidney transplantation significantly improved the ejection fraction (EF) (treatment effect = 4.23 ± 2.06%; P = 0.046) and apical 4-chamber strain (treatment effect = -0.89 ± 0.37%; P = 0.021) in the patients. It also reduced the LV mass index (treatment effect = -73.82 ± 11.6; P < 0.001) and relative wall thickness (treatment effect = -0.056±0.023; P = 0.021). Other variables including global longitudinal strain and diastolic dysfunction were not improved significantly. Conclusion: STE may show early improvements in myocardial function 1 month after renal transplantation.

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“…I. Wen 1,2, * , K. Gu 1,2 , A. Bhat 1,2,3 , H. Chen 1,2 , M. Kayes 2 , G. Gan 1,2,3,4 Background: Chronic Kidney Disease (CKD) is associated with adverse cardiac remodelling, most notably left ventricular (LV) hypertrophy and LV diastolic dysfunction, [1][2][3] the presence of which has been associated with adverse cardiovascular outcomes [4]. Despite this, transthoracic echocardiography (TTE) is not routinely performed in this population, limiting opportunities for early effective intervention.…”

Section: Utility Of Transthoracic Echocardiograms In Patients With Chmentioning

confidence: 99%

Utility of the Mitral Valve Doppler Velocity Index in Detecting Significant Mitral Regurgitation Post-Surgical Mitral Valve Repair

Anderson

Scalia

Burstow

2019

Heart, Lung and Circulation

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Common echocardiography findings in pretransplant dialysis patients and their associations

Cited by 6 publications

References 31 publications

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study

The effect of kidney transplantation on speckled tracking echocardiography findings in patients on hemodialysis

Utility of the Mitral Valve Doppler Velocity Index in Detecting Significant Mitral Regurgitation Post-Surgical Mitral Valve Repair

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Common echocardiography findings in pretransplant dialysis patients and their associations

Cited by 6 publications

References 31 publications

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania &mdash;&nbsp;a cross-sectional study

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania &mdash;&nbsp;a cross-sectional study

The effect of kidney transplantation on speckled tracking echocardiography findings in patients on hemodialysis

Utility of the Mitral Valve Doppler Velocity Index in Detecting Significant Mitral Regurgitation Post-Surgical Mitral Valve Repair

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Product

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Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study

Prevalence and predictors of left ventricular dysfunction among patients with chronic kidney disease attending Muhimbili National Hospital in Tanzania — a cross-sectional study