Common endocrine disorders associated with the polycystic ovary syndrome

Abdelazim, Ibrahim A.; Karimova, Bakyt; Farghali, Mohamed M.

doi:10.5114/pm.2020.101948

Cited by 18 publications

(20 citation statements)

References 16 publications

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“…We additionally adjusted our tests for variation in BMI, so the associations we report are not likely to be confounded by the BMI of the participants, unless reported otherwise. The individuals with PCOS also had higher blood glucose, prolactin and TSH levels (Tables 1 and S1) consistent with earlier reports [55]. It is of note that both fasting glucose and prolactin were increased among our case group and at the same time we saw linear associations between decreased abundance of family Peptococcaceae and lower prolactin, and increased abundance of genera Collinsela and Paraprevotella and fasting glucose, when looking at the whole population.…”

Section: Discussionsupporting

confidence: 91%

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Hassan

Kaakinen

Draisma

et al. 2022

Genes

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Polycystic ovary syndrome (PCOS) is a very common endocrine condition in women in India. Gut microbiome alterations were shown to be involved in PCOS, yet it is remarkably understudied in Indian women who have a higher incidence of PCOS as compared to other ethnic populations. During the regional PCOS screening program among young women, we recruited 19 drug naive women with PCOS and 20 control women at the Sher-i-Kashmir Institute of Medical Sciences, Kashmir, North India. We profiled the gut microbiome in faecal samples by 16S rRNA sequencing and included 40/58 operational taxonomic units (OTUs) detected in at least 1/3 of the subjects with relative abundance (RA) ≥ 0.1%. We compared the RAs at a family/genus level in PCOS/non-PCOS groups and their correlation with 33 metabolic and hormonal factors, and corrected for multiple testing, while taking the variation in day of menstrual cycle at sample collection, age and BMI into account. Five genera were significantly enriched in PCOS cases: Sarcina, Megasphaera, and previously reported for PCOS Bifidobacterium, Collinsella and Paraprevotella confirmed by different statistical models. At the family level, the relative abundance of Bifidobacteriaceae was enriched, whereas Peptococcaceae was decreased among cases. We observed increased relative abundance of Collinsella and Paraprevotella with higher fasting blood glucose levels, and Paraprevotella and Alkalibacterium with larger hip, waist circumference, weight, and Peptococcaceae with lower prolactin levels. We also detected a novel association between Eubacterium and follicle-stimulating hormone levels and between Bifidobacterium and alkaline phosphatase, independently of the BMI of the participants. Our report supports that there is a relationship between gut microbiome composition and PCOS with links to specific reproductive health metabolic and hormonal predictors in Indian women.

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Section: Discussionsupporting

confidence: 91%

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Hassan

Kaakinen

Draisma

et al. 2022

Genes

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“…Glintborg, D. et al found an increased risk of hypothyroidism, Graves' disease, goiter, and thyroiditis in the Danish population with PCOS [3]. Similar ndings have been found in many studies [4][5][6][7][8][9]. A recent large sample meta-analysis study [10,11] also revealed a strong association between thyroid disease and PCOS.…”

Section: Introductionsupporting

confidence: 62%

The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

2022

Preprint

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Background Observational studies have found a correlation between thyroid diseases and polycystic ovary syndrome (PCOS). However, their causal relationship remains uncertain. Our purpose was to investigate the causal relationship between four common thyroid diseases (hypothyroidism, hyperthyroidism, autoimmune thyroiditis, thyroid cancer) and PCOS risk. Methods In this study, using the Mendelian randomization (MR) approach, we obtained single nucleotide polymorphisms (SNPs) from the genome-wide association study (GWAS) database as instrumental variables (IVs) and used inverse variance weighting (IVW) to explore the causal relationship between four common thyroid diseases and PCOS. Results We found a significant causal association between hypothyroidism and increased risk of PCOS [OR = 34.90, 95% CI: (1.68, 724.53), P = 0.02]. However, hyperthyroidism, autoimmune thyroiditis, thyroid cancer has no significant causal association with PCOS. Conclusion Hypothyroidism may increase the risk of PCOS. Hyperthyroidism, autoimmune thyroiditis, thyroid cancer has no significant causal association with PCOS.

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“…The BMI was calculated from the studied adolescents' body weight and their height (kg/m 2 ). The WHO considered ≤ 24.9 kg/m 2 normal-weight, 25.0-29.9 kg/m 2 overweight, and > 30 Kg/m 2 obesity class-I [20].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Donayeva

Amanzholkyzy

Nurgaliyeva

et al. 2023

Preprint

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Background: The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation. Objective: This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea. Methods: Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared with matched controls (210 controls), after informed consent following the Helsinki Declaration. After thorough evaluation, and pelvic ultrasound examination, blood samples were collected from the studied adolescents for measuring the serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. Collected data were analyzed using the Pearson`s correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with TaqI (rs731236) polymorphism. Results: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P=0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D, and visual analogue scale of dysmenorrhea (r=-0.9003, P<0.0001). The studied-dysmenorrhea cases with T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P=0.02 and 0.004, respectively). The odds of primary dysmenorrhea were significantly higher in T/t and t/t genotypes (OR 1367.2, P<0.0001, and 106.2, P=0.001, respectively). Conclusion: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The odds of primary dysmenorrhea were significantly higher in T/t and t/t TaqI genotypes.

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Common endocrine disorders associated with the polycystic ovary syndrome

Cited by 18 publications

References 16 publications

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

The influence of hypothyroidism, hyperthyroidism, autoimmune thyroiditis and thyroid cancer on the risk of polycystic ovary syndrome: a Mendelian Randomization study

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

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