True atherosclerotic aneurysms of the common femoral artery (CFA) are rare and often associated with other peripheral or aortic aneurysms. Degenerative aneurysms of the lower extremity most commonly involve the popliteal artery, while they are rarely detected in the femoral region. In this region, aneurysms most frequently involve the common femoral artery (CFA), whereas true aneurysms of the superficial femoral artery (SFA) represent only 15% to 25% of femoral arterial aneurysms.We report a case of an 84-year-old patient presenting a degenerative thrombosed aneurysm of the CFA and critical limb ischemia. After an accurate workout, the patient underwent successful aneurysmectomy and bypass grafting, with a satisfying mild-term follow-up and patency of the graft. The patient came back presenting surgical site infection (SSI) and wound dehiscence that was successfully treated with the Vacuum Assisted Therapy (V.A.C.® therapy) and accurate medical therapy.Aneurysmectomy and revascularization of the distal CFA with an artificial blood vessel graft were performed, associated with revascularization and stenting of the left femoral-iliac axis. CFA aneurysms are rare and have a low rate of rupture but high risk of complications like embolic or thrombotic lower limb ischemia with challenging treatment solutions. Nowadays open vascular surgery, sometimes in association with the endovascular procedure, plays an important role in the treatment of this pathology.