Common gamma chain (¿c) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8 + T cells

Abstract

Background: Several members of the common gamma chain (gc) cytokine family are already approved (IL-2) or actively being developed as vaccine adjuvants and cancer immunotherapies. Studies have indicated that co-administration of gc cytokines may enhance the efficacy of immunotherapies that function via direct activation of co-stimulatory T cell receptors. To define the specific influence of gc cytokines on the co-stimulatory capacity of CD8 + T cells and identify combinations with synergistic potential, we investigated the direct impact of gc cytokines on the differentiation and transcriptional profile of recently antigen-primed CD8 + T cells.

Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8+ T Cell Development

“…This IL-2/IL-2R signaling is essential for OX40-mediated differentiation of CD8 + T cells (14,15). IL-2 is one of the first cytokines secreted by T cells following TCR stimulation and has multifaceted effects on T cells, including inducing proliferation, promoting survival, and sustaining T cell expansion (1,16). The high-affinity IL-2R consists of a trimeric complex of the IL-2Ra (CD25), IL-2Rb (CD122), and common gc (CD132) subunits.…”