Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases (review)

Loktionov, Alexandre

doi:10.1016/s0955-2863(03)00032-9

Cited by 142 publications

(102 citation statements)

References 264 publications

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“…Energy balance in body is very important and this is controlled by several polymorphic genes encoding taste receptors. Loktionov (2003) reported that food intake is affected by several signalling molecules such as leptin, insulin and cholecystokinin and their corresponding receptors. While, Gaboon (2011) stated that several central energy regulators such as CART (cocaine and amphetamineregulated transcript), hypothalamic neuropeptide Y, melanocortin pathway factors etc.…”

Section: Nutrigenomics and Human Healthmentioning

confidence: 99%

Applications of Nutrigenomics in Animal Sectors: A Review

Banerjee¹,

Pal²,

Ray³

2015

Asian J. of Animal and Veterinary Advances

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Nutrigenomics is the study of gene expression or metabolic pathway depending on different food material. In recent year, nutrigenomics has gained special attention due to its great potentiality for treating chronic disease. In this review, we have emphasized the importance of nutrigenomics on human health and on animal farm, specially on pork and poultry industries. Types of food consumption are crucial factor for human health in term of specific nutrition related gene expression and this knowledge is important for preparation of personalized diet. Human genome project identified several polymorphic gene and few of them are involved in metabolic pathway. The present review demonstrated the metabolism related disease like lactose intolerance and phenylketoneuria which is occurred due to polymorphic nature of that particular gene. Due to high cost of raw material, feed efficiency in pork and poultry industries is a crucial factor. In several investigations, researchers have used different combination of food material to monitor the growth and health of pig and chicken but it needs more accuracy and better understanding. Though the food product development and field application technique has a long way to go, further development in the field of nutrigenomics will definitely show it's potentiality in the food market and the growth of individuals. A greater understanding of these mechanisms will lead us to a sustainable fisheries, more production and other aquaculture activities.

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Section: Nutrigenomics and Human Healthmentioning

confidence: 99%

Applications of Nutrigenomics in Animal Sectors: A Review

Banerjee¹,

Pal²,

Ray³

2015

Asian J. of Animal and Veterinary Advances

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“…few genes with large measurable effects often expressed on a residual polygenic background). Indeed, it is this oligogenic architecture that warrants all current efforts to map genes for complex phenotypes [19,20].…”

Section: Genetic Risk Factorsmentioning

confidence: 99%

“…Initially such effort to identify specific genes influencing complex traits such as those associated with obesity relied on the use of a priori defined candidates genes [3,19]. Such candidate genes are selected on the basis of their perceived role or function in biochemical pathways relevant to the specific phenotype of interest (e.g.…”

Section: Genetic Risk Factorsmentioning

confidence: 99%

“…Hypothalamic and brain stem centres are involved in the regulation of food intake and energy balance, but information on the relevant regulatory factors was scarce before the last decade [3,19]. Insulin remained the only candidate with a key role in body weight regulation for a long time until the discovery of leptin.…”

Section: Genes Encoding Factors Regulating Food/energy Intakementioning

confidence: 99%

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Genetics of Obesity: Gene × Nutrient Interactions

Martí

Martínéz

2006

International Journal for Vitamin and Nutrition Research

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Obesity results from a long-term positive energy balance, in which gene-related differences may account for some of the disparities found in weight gain among populations. However, the rising prevalence of obesity in developed and developing societies must reflect lifestyle changes. Despite that the genetic background remains stable over many generations, obesity may be derived from a failure on the homeostasis systems, as a consequence of a dysfunction at the genetic level, which may be affected by changing environmental exposure (dietary habits, sedentarism, etc). In practice, obesity risk at least depends on two important factors, which mutually interact: 1) genetic variants and gene expression changes in candidate genes and 2) exposure to environmental risk factors. Disagreements among studies involving gene-nutrient interactions may reflect the difficulty of accurate measurement of specific types of dietary macro and micronutrients intake as well of phenotype assessment rather than a discrepancy in biological relevance. Identification of individuals who are genetically more likely to respond to particular dietary changes may be important for successful intervention in obesity treatment, since gene screening will allow health professionals to tailor-design weight management and dietary guidance in individuals with a genetic predisposition to become obese.

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“…Indeed, both hormones are secreted proportionally to body fat content and target the hypothalamus (Figure 1). By acting on hypothalamic neurones, insulin and leptin repress the expression of genes involved in anabolic neural circuits that stimulate eating and activate catabolic genes that inhibit food intake and increase energy expenditure (Loktionov, 2003). FIGURE 1.…”

Section: Ii1 Adiposity Signals Acting On Neurons: An Emerging Concementioning

confidence: 99%

Genes involved in obesity: Adipocytes, brain and microflora

et al. 2006

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Obesity and obesity-related disorders such as cardiovascular diseases and metabolic abnormalities including hypertension, hyperinsulinemia, insulin-resistance and type 2 diabetes, are among the most pressing problems in the industrialized world (Friedman, 2003;Kannel et al., 1991 (Reitman et al., 2000), demonstrating that normal adipose tissue development and function is critical for metabolic homeostasis.Obesity results from complex interactions between genes and environmental factors such as diet, food components and/or way of life, and can be viewed as an energy storage disorder in which weight gain results from an energy imbalance (i.e. energy input exceeding output), with most of the excess calories stored as triglycerides in adipose tissue (Smith et al., 2006). Therefore a great deal of attention has focused on the mechanisms controlling food intake and adipose mass, and is of considerable importance for public health and clinical medicine.In this review, we prevalently highlight the complex relationships existing between the white adipose tissue, the central nervous system, the endogenous microbiota, and nutrition. Throughout, we emphasize the most recent findings in the field and consider how it shapes the past knowledge and forecasts the future of research on metabolic disorders, such as obesity.

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Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases (review)

Cited by 142 publications

References 264 publications

Applications of Nutrigenomics in Animal Sectors: A Review

Applications of Nutrigenomics in Animal Sectors: A Review

Genetics of Obesity: Gene × Nutrient Interactions

Genes involved in obesity: Adipocytes, brain and microflora

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