Common hematological parameters reference intervals for apparently healthy pregnant and non-pregnant women of South Wollo Zone, Amhara Regional State, Northeast Ethiopia

Fiseha, Mesfin; Mohammed, Miftah; Ebrahim, Endris; Demsiss, Wondmagegn; Tarekegn, Mohammed; Angelo, Amanuel; Negash, Mikias; Tamir, Zemenu; Tilahun, Mihret; Tsegaye, Aster

doi:10.1371/journal.pone.0270685

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…Given the intricate and diverse nature of the risk factors associated with pre-eclampsia, numerous prediction models have been developed, each varying in reported e cacy. For instance, the pre-eclampsia prediction method recommended by the UK Fetal Medicine Foundation requires the standard measurement of the uterine artery pulsatility index and the measurement of placental growth factor (PlGF) [9]. However, both of these indicators face certain di culties in promotion in China, as monitoring of uterine blood dynamics depends on necessary equipment and detection techniques, which are di cult to promote on a large scale in underdeveloped areas [10].…”

Section: Discussionmentioning

confidence: 99%

Construction of a Risk Prediction Model for Pre-eclampsia in Northern China: A Study of 798 Hospitalized Pregnant Women

Chen,

Li,

et al. 2024

Preprint

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Objective To screen the risk factors for pre-eclampsia in Northern China and construct a risk prediction model. Methods Clinical data of 798 hospitalized pregnant women from March 2023 to August 2023 at the First Hospital of Jilin University were collected and analyzed. The patients were divided into a pre-eclampsia group (N = 176, case group) and a non-pre-eclampsia group (622 cases, control group) based on clinical diagnosis. Patient medical history, family history, early pregnancy diagnostic data from prenatal care handbooks, and lifestyle information during pregnancy were collected, resulting in a total of 106 parameters for analysis. Univariate analysis and logistic regression analysis were used to identify independent risk factors associated with pre-eclampsia. Subsequently, ROC curve analysis was conducted to evaluate the predictive performance of the model, and a disease prediction model was constructed. Results (1) Independent risk factors for pre-eclampsia during early pregnancy included a history of pre-eclampsia, chronic hypertension, family history of hypertension, systolic blood pressure ≥ 120mmHg, diastolic blood pressure ≥ 80mmHg, education level, daily intake of dairy products > 100mL, education level of college or above, and white blood cell count > 1.3×109/L. (2) The probability (P) of prediction was calculated based on these factors using the formula P = 1/[1 + EXP(-1.670 + 3.326×history of pre-eclampsia + 3.151×history of chronic hypertension + 1.276×family history of hypertension + 0.786×systolic blood pressure ≥ 120mmHg + 3.205×diastolic blood pressure ≥ 80mmHg + 0.625×daily intake of dairy products > 100mL-0.792×education level of college or above + 1.000×white blood cell count > 1.3×109/L)]. (3) The area under the ROC curve based on this data was 0.804 [95% CI (0.756, 0.852)], P<0.05. (4) Validation of the model among 107 pregnant women, yielded an accuracy rate of 82.24%. Conclusion The risk prediction model, developed using identified risk factors, effectively predicts pre-eclampsia risk in high-risk individuals, offering valuable guidance for clinicians' decision-making.

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Section: Discussionmentioning

confidence: 99%

Construction of a Risk Prediction Model for Pre-eclampsia in Northern China: A Study of 798 Hospitalized Pregnant Women

Chen,

Li,

et al. 2024

Preprint

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“…A retrospective cross-sectional descriptive study [44][45][46][47][48][49][50][51][52] of apparently healthy non-pregnant women of reproductive age who did CBC laboratory test between 2020-2021 at the study site as part of routine employment or immigration or scholarship check.…”

Section: Methodsmentioning

confidence: 99%

"An Assessment of Complete Blood Count for Anaemia Evaluation Among Healthy Women of Reproductive Age in Freetown, Sierra Leone"

Wurie

2024

BJSTR

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Background: Complete blood count (CBC) parameters which are useful markers of anaemia vary across population. Anaemia is highly prevalent in women of reproductive age in Sub-Sahara Africa, and the very high rate of maternal mortality in lowincome countries has been attributed to haematological complications such as anaemia and thrombocytopenia among other common causes. This study therefore, aims at exploring the result statistics of CBC parameters amongst a healthy population. Specific objectives are to evaluate the mean, median and range of Haemoglobin (Hb), Red cell count (RBC), Mean Corpuscular Volume (MCV), White Blood Cell Count (WBC) and Platelet (PLT) count using automated analysers and result validated with external quality assessment report. Their indicators were also used to analyse for the prevalence of anaemia, thrombocytopenia and thrombocytosis.Methods: A retrospective, cross-sectional study was conducted on healthy non-pregnant women of reproductive age (18-40years), with normal chest X-ray and ECG report between 2020 and 2022. The samples were derived from archived databank that de-identified all personal data including requesting clinicians. A total of 252 data of eligible participants meeting the acceptance criteria were used in the final analysis. Results:The mean, median and range of the haematological parameters were: Hb (g/dl) mean=10.6, median=10.6, range=4.8-13.3; RBC (x1012/l) mean=4. 56, median=4.43, MCV (fl) mean=83.5, median=84.5, WBC (x109/l) mean= 5.5, median=5.3,; PLT (x109/l) mean=203, median=193, range=85-1033. Using the WHO criteria for anaemia, the prevalence of anaemia in the population was 89.7% of which the defined moderate-anaemia was the predominant degree of anaemia (63.5%). The result further showed a 13.9% thrombocytopenia while thrombocytosis was at 0.8%. Conclusion:A prevalence of 89.7% is high and although most of this fall within the moderate anaemia range, it is still a public health threat to women of reproductive age and thus could contribute poor maternal and foetal health outcomes. Furthermore, the high thrombocytopenia may also impact on pregnancy outcome if untreated. The values of haematological parameters from this study differ from values derived from non-African population as well some African countries, thus there is need to establish the reference range for Sierra Leone as this will give a better picture of the actual situation.

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Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets

Barakauskas,

Bohn,

Branch

et al. 2023

Clinical Chemistry

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Background Physiological changes during pregnancy invalidate use of general population reference intervals (RIs) for pregnant people. The complete blood count (CBC) is commonly ordered during pregnancy, but few studies have established pregnancy RIs suitable for contemporary Canadian mothers. Prospective RI studies are challenging to perform during pregnancy while retrospective techniques fall short as pregnancy and health status are not readily available in the laboratory information system (LIS). This study derived pregnancy RIs retrospectively using LIS data linked to provincial perinatal registry data. Methods A 5-year healthy pregnancy cohort was defined from the British Columbia Perinatal Data Registry and linked to laboratory data from two laboratories. CBC and differential RIs were calculated using direct and indirect approaches. Impacts of maternal and pregnancy characteristics, such as age, body mass index, and ethnicity, on laboratory values were also assessed. Results The cohort contained 143 106 unique term singleton pregnancies, linked to >972 000 CBC results. RIs were calculated by trimester and gestational week. Result trends throughout gestation aligned with previous reports in the literature, although differences in exact RI limits were seen for many tests. Trimester-specific bins may not be appropriate for several CBC parameters that change rapidly within trimesters, including red blood cells (RBCs), some leukocyte parameters, and platelet counts. Conclusions Combining information from comprehensive clinical databases with LIS data provides a robust and reliable means for deriving pregnancy RIs. The present analysis also illustrates limitations of using conventional trimester bins during pregnancy, supporting use of gestational age or empirically derived bins for defining CBC normal values during pregnancy.

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Common hematological parameters reference intervals for apparently healthy pregnant and non-pregnant women of South Wollo Zone, Amhara Regional State, Northeast Ethiopia

Cited by 5 publications

References 40 publications

Construction of a Risk Prediction Model for Pre-eclampsia in Northern China: A Study of 798 Hospitalized Pregnant Women

Construction of a Risk Prediction Model for Pre-eclampsia in Northern China: A Study of 798 Hospitalized Pregnant Women

"An Assessment of Complete Blood Count for Anaemia Evaluation Among Healthy Women of Reproductive Age in Freetown, Sierra Leone"

Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets

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