Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

McCormack, Meredith C.; Breysse, Patrick N.; Hansel, Nadia N.; Matsui, Elizabeth C.; Tonorezos, Emily S.; Curtin-Brosnan, Jean; Williams, D’Ann L.; Buckley, Timothy J.; Eggleston, Peyton A.; Diette, Gregory B.

doi:10.1016/j.envres.2007.08.012

Cited by 108 publications

(105 citation statements)

References 20 publications

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“…Current recommendations for improving home indoor air quality focus mostly on avoiding indoor SHS. However, our findings are likely independent of SHS exposure, and there are other important modifiable sources of indoor PM and NO 2 (20,40). Future studies investigating the effectiveness of environmental interventions aimed at reducing indoor pollutant concentrations in homes of patients with COPD, such air cleaner intervention trials that have shown reduction in indoor PM and improved symptoms in asthma (10), are warranted as potential nonpharmacologic approaches to improving COPD health.…”

Section: Discussionmentioning

confidence: 78%

“…Our results are derived from a population in Baltimore City and surrounding areas and the indoor environment may not be generalizable to other communities. In addition, we did not measure outdoor or personal exposure to PM and NO 2 ; however, previous results from Baltimore City homes show that although outdoor PM and NO 2 concentrations contribute to indoor concentrations, indoor sources, such as smoking, cooking, combustion sources, and cleaning practices, are the dominant determinants of indoor pollutant concentrations (20,40). To confirm a similar association in our sample of homes of subjects with COPD, in a subgroup (n ¼ 26) of our participants who lived within 3 miles of an outdoor monitoring station, we found that outdoor PM 2.5 concentrations explained only 5% of the variance in indoor PM 2.5 concentrations; outdoor NO 2 concentrations explained approximately 25% of the variance in indoor NO 2 concentrations.…”

Section: Discussionmentioning

confidence: 99%

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In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Hansel¹,

McCormack²,

Belli³

et al. 2013

Am J Respir Crit Care Med

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102

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Rationale: The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. Objectives: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO 2 ) concentrations on COPD morbidity in a periurban community. Methods: Former smokers with COPD were recruited and indoor air was monitored over a 1-week period in the participant's bedroom and main living area at baseline, 3 months, and 6 months. At each visit, participants completed spirometry and questionnaires assessing respiratory symptoms. Exacerbations were assessed by questionnaires administered at clinic visits and monthly telephone calls. Measurements and Main Results: Participants (n ¼ 84) had moderate or severe COPD with a mean FEV 1 of 48.6% predicted. The mean (6 SD) indoor PM 2.5 and NO 2 concentrations were 11.4 6 13.3 µg/m 3 and 10.8 6 10.6 ppb in the bedroom, and 12.2 6 12.2 µg/m 3 and 12.2 6 11.8 ppb in the main living area. Increases in PM 2.5 concentrations in the main living area were associated with increases in respiratory symptoms, rescue medication use, and risk of severe COPD exacerbations. Increases in NO 2 concentrations in the main living area were independently associated with worse dyspnea. Increases in bedroom NO 2 concentrations were associated with increases in nocturnal symptoms and risk of severe COPD exacerbations. Conclusions: Indoor pollutant exposure, including PM 2.5 and NO 2 , was associated with increased respiratory symptoms and risk of COPD exacerbation. Future investigations should include intervention studies that optimize indoor air quality as a novel therapeutic approach to improving COPD health outcomes.Keywords: indoor air; chronic obstructive pulmonary disease; particulate matter; nitrogen dioxide; exacerbations Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States and the fifth leading cause worldwide, is expected to become increasingly prevalent in upcoming decades (1, 2). Most COPD is caused by environmental exposures; in developed countries, this exposure is primarily cigarette smoke. After COPD begins, evidence indicates that it can be worsened by other environmental exposures. For example, outdoor particulate matter (PM) concentrations have been associated with an increase in COPD hospitalizations and mortality (3, 4). Similarly, outdoor nitrogen dioxide (NO 2 ) exposure has been linked to worse COPD morbidity, including higher rates of exacerbations (4-6).Although substantial evidence shows that outdoor air pollutants impact COPD, there is much less evidence for the impact of indoor air on COPD, especially in developed countries. Although the Global Initiative for Chronic Obstructive Lung Disease guidelines identify indoor air pollution resulting from burning wood and other biomass fuels as a major risk factor for COPD (7), exposures under these conditions are two to three orders of magnitude higher ...

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Hansel¹,

McCormack²,

Belli³

et al. 2013

Am J Respir Crit Care Med

Self Cite

102

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“…Human-made sources consist of industrial emissions and combustion by-products from incinerators, motor vehicles, and power plants. Indoor sources include cigarette smoking, cooking, wood and other biomass burning in stoves and fireplaces, cleaning activities that re-suspend dust particles (e.g., sweeping), and penetration of outdoor particles into the indoor environment (11,12). Indoor PM differs from outdoor PM in source, composition, and concentration (11,(13)(14)(15)(16).…”

Section: Indoor Particulate Mattermentioning

confidence: 99%

“…A longitudinal study of 150 inner city preschool children with asthma, conducted as a part of the Johns Hopkins Center Significant determinants of indoor PM concentrations included smoking, sweeping, and stove use (19), activities that are modifiable and provide opportunities for exposure reduction. Smoking has been consistently described as a major source of indoor particulates over the last several decades, with more than 30% of all U.S. children exposed to secondhand smoke (20).…”

Section: Indoor Particulate Mattermentioning

confidence: 99%

Indoor Air Pollution and Asthma in Children

Breysse¹,

Diette²,

Matsui³

et al. 2010

Proceedings of the American Thoracic Society

189

108

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“…Cigarette smoke is a major contributor to indoor PM in US homes, because each half-pack of cigarettes smoked in the home is estimated to contribute 4.0 μg/m 3 of PM, 7, 60 and approximately 30% of all US children and 40% to 60% of US children in low-income households are exposed to SHS in their homes. 7,65,66 Smoking cessation by close family members and caregivers is the most effective way to reduce or eliminate tobacco smoke exposure.…”

Section: Shsmentioning

confidence: 99%

Indoor Environmental Control Practices and Asthma Management

Matsui¹,

Abramson²,

Sandel³

et al. 2016

Pediatrics

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Indoor environmental exposures, particularly allergens and pollutants, are major contributors to asthma morbidity in children; environmental control practices aimed at reducing these exposures are an integral component of asthma management. Some individually tailored environmental control practices that have been shown to reduce asthma symptoms and exacerbations are similar in efficacy and cost to controller medications. As a part of developing tailored strategies regarding environmental control measures, an environmental history can be obtained to evaluate the key indoor environmental exposures that are known to trigger asthma symptoms and exacerbations, including both indoor pollutants and allergens. An environmental history includes questions regarding the presence of pets or pests or evidence of pests in the home, as well as knowledge regarding whether the climatic characteristics in the community favor dust mites. In addition, the history focuses on sources of indoor air pollution, including the presence of smokers who live in the home or care for children and the use of gas stoves and appliances in the home. Serum allergen-specific immunoglobulin E antibody tests can be performed or the patient can be referred for allergy skin testing to identify indoor allergens that are most likely to be clinically relevant. Environmental control strategies are tailored to each potentially relevant indoor exposure and are based on knowledge of the sources and underlying characteristics of the exposure. Strategies include source removal, source control, and mitigation strategies, such as high-efficiency particulate air purifiers and allergen-proof mattress and pillow encasements, as well as education, which can be delivered by primary care pediatricians, allergists, pediatric pulmonologists, other health care workers, or community health workers trained in asthma environmental control and asthma education.

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Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

Cited by 108 publications

References 20 publications

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Indoor Air Pollution and Asthma in Children

Indoor Environmental Control Practices and Asthma Management

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