Common Metabolic Profile in Infants Indicating Impaired Cobalamin Status Responds to Cobalamin Supplementation

Bjørke‐Monsen, Anne‐Lise; Torsvik, Ingrid Kristin; Sætran, Hege Aase; Markestad, Trond; Ueland, Per Magne

doi:10.1542/peds.2007-2716

Cited by 57 publications

(81 citation statements)

References 214 publications

(357 reference statements)

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“…The most repeated reason for risk of bias across the studies was an inadequate explanation about the drop-outs and an inadequate assessment of exposure (method to assess vitamin B 12 intakes). (31) ) or MMA (two studies (28,31) , while in one study (31) , associations were not found for MMA).…”

Section: Pregnant and Lactating Womenmentioning

confidence: 93%

“…In the RCT from Bjorke-Monsen et al (28) , the intervention was the strongest predictor of changes for all blood indices (regression coefficient 5 183 for serum vitamin B 12 In the Guatemalan cross-sectional study (30) , mean intake of vitamin B 12 was 3?1 mg/d for mothers and 2?2 mg/d for infants at the age of 12 months and the accompanying mean (SD) plasma vitamin B 12 concentration in mothers and infants was 114?4 (9?2) g/l and 262?2 (163?5) pmol/l, respectively. The plasma vitamin B 12 concentrations of the infants were correlated with maternal concentrations and they were also positively associated with infant B 12 intake from complementary foods (r 5 0?16, P , 0?0001).…”

Section: Infantsmentioning

confidence: 99%

“…However, reports on short-and long-term neurological effects related to vitamin B 12 deficiency in young infants demonstrate the importance of an adequate vitamin B 12 status during the first months of life (28) . Vitamin B 12 is also suggested to be related with neurocognitive function in school-aged children (50) .…”

Section: Cognitive Functionmentioning

confidence: 99%

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Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Iglesia¹,

Dhonukshe-Rutten²,

Bel‐Serrat³

et al. 2012

Public Health Nutr.

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Objective: To review evidence on the associations between vitamin B 12 intake and its biomarkers, vitamin B 12 intake and its functional health outcomes, and vitamin B 12 biomarkers and functional health outcomes. Design: A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review. Setting: Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3). Subjects: Population groups included healthy infants, children and adolescents, and pregnant and lactating women. Results: From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women. Conclusions: Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B 12 intake and serum vitamin B 12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B 12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B 12 in young populations.

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Section: Pregnant and Lactating Womenmentioning

confidence: 93%

Section: Infantsmentioning

confidence: 99%

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Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Iglesia¹,

Dhonukshe-Rutten²,

Bel‐Serrat³

et al. 2012

Public Health Nutr.

View full text Add to dashboard Cite

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“…In a randomized study in Norway, intramuscular injection of 400 μg of vitamin B12 to infants (n = 54) at 6 weeks raised serum B12 (IQR: 291-497 pmol/L), and lowered MMA (from 0.58 to 0.20 μmol/L) and tHcy (from 7.46 to 4.57 μmol/L) at 4 months, compared to a group (n=51) that received no intervention [86]. Despite the high prevalence of vitamin B12 deficiency amongst pregnant and breastfeeding women and their infants, there is a paucity of information on infant development in response to vitamin B12 supplementation during pregnancy or infancy.…”

Section: Citationmentioning

confidence: 99%

“…Monsen et al [86] RCT in Norway. n=107 infants (6 wk) randomized to receive either an intramuscular injection of B12 (400 μg) or no intervention (control).…”

Section: Citationmentioning

confidence: 99%

Vitamin B12 Deficiency in Pregnancy and Lactation: Is there a Need for Pre and Post-natal Supplementation?

Siddiqua¹,

Allen²,

Raqib³

et al. 2014

J Nutr Disorders Ther

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This article reviews vitamin B12 (B12) status and deficiency during pregnancy and lactation, its effect on pregnancy, and the health of the offspring, with the aim to underscore the need for a sustainable strategy to improve maternal and infant vitamin B12 status of low and middle income countries. Vitamin B12 is a basic nutrient required for maintenance of normal erythropoiesis, cell reproduction, nucleoprotein and myelin synthesis. B12 deficiency is associated with adverse pregnancy outcomes and neurodevelopmental morbidity during infancy. Very few studies have indicated that B12 deficiency may contribute to altered immune responses in animals and humans. Additionally, no studies have shown modulation of infant motor development in response to maternal B12 supplementation. Despite the high global prevalence of B12 deficiency and its serious effects on pregnant women and offspring, there is still no consensus on the cut-off of biochemical markers (indicator of B12 deficiency) to correctly diagnose B12 deficiency in mother-infant dyad. Also, the optimum dose of B12 to normalize B12 status of mother-infant pairs in a deficient population is not known yet. In addition, markers of other functions such as neurodevelopment, immune response that may be affected by vitamin B12 deficiency should be measured to determine if they respond to supplementation. Thus, there is an urgent need to conduct more trials to find out the optimum dose, to investigate whether intervention with such pre-and post natal vitamin B12 supplementation would improve maternal, neonatal and child health outcomes in population at risk, giving emphasis on neurological processes, immune functions and epigenetic modifications. Other strategies including food based approach also require evidence based results which will help to understand effectiveness of a targeted and well-designed intervention among this population.

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Regional Brain Morphometry and Impulsivity in Adolescents Following Prenatal Exposure to Cocaine and Tobacco

Liu

Lester²,

Neyzi³

et al. 2013

JAMA Pediatr

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Importance Animal studies have suggested that prenatal cocaine exposure (PCE) deleteriously influences the developing nervous system, in part attributable to its site of action in blocking the function of monoamine reuptake transporters, increasing synaptic levels of serotonin and dopamine. Objective To examine the brain morphologic features and associated impulsive behaviors in adolescents following prenatal exposure to cocaine and/or tobacco. Design Magnetic resonance imaging data and behavioral measures were collected from adolescents followed up longitudinally in the Maternal Lifestyle Study. Setting A hospital-based research center. Participants A total of 40 adolescent participants aged 13 to 15 years were recruited, 20 without PCE and 20 with PCE; a subset of each group additionally had tobacco exposure. Participants were selected and matched based on head circumference at birth, gestational age, maternal alcohol use, age, sex, race/ethnicity, IQ, family poverty, and socioeconomic status. Main Outcome Measures Subcortical volumetric measures of the thalamus, caudate, putamen, pallidum, hippocampus, amygdala, and nucleus accumbens; cortical thickness measures of the dorsolateral prefrontal cortex and ventral medial prefrontal cortex; and impulsivity assessed by Conners' Continuous Performance Test and the Sensation Seeking Scale for Children. Results After controlling for covariates, cortical thickness of the right dorsolateral prefrontal cortex was significantly thinner in adolescents following PCE (P=.03), whereas the pallidum volume was smaller in adolescents following prenatal tobacco exposure (P=.03). Impulsivity was correlated with thalamic volume following either PCE (P=.05) or prenatal tobacco exposure (P=.04). Conclusions and Relevance Prenatal cocaine or tobacco exposure can differentially affect structural brain maturation during adolescence and underlie enhanced susceptibility to impulsivity. Additional studies with larger sample sizes are warranted.

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Common Metabolic Profile in Infants Indicating Impaired Cobalamin Status Responds to Cobalamin Supplementation

Cited by 57 publications

References 214 publications

Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Vitamin B12 Deficiency in Pregnancy and Lactation: Is there a Need for Pre and Post-natal Supplementation?

Regional Brain Morphometry and Impulsivity in Adolescents Following Prenatal Exposure to Cocaine and Tobacco

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Common Metabolic Profile in Infants Indicating Impaired Cobalamin Status Responds to Cobalamin Supplementation

Cited by 57 publications

References 214 publications

Association between vitamin B12intake and EURRECA's prioritized biomarkers of vitamin B12in young populations: a systematic review

Association between vitamin B12intake and EURRECA's prioritized biomarkers of vitamin B12in young populations: a systematic review

Vitamin B12 Deficiency in Pregnancy and Lactation: Is there a Need for Pre and Post-natal Supplementation?

Regional Brain Morphometry and Impulsivity in Adolescents Following Prenatal Exposure to Cocaine and Tobacco

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Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review