Common microbial causes of significant bacteriuria and their antibiotic resistance pattern in the Isfahan Province of Iran

Najafabadi, Maryam Pezeshki; Dagoohian, Afsaneh; Rajaie, Soheila; Zarkesh-Esfahani, Sayyed Hamid; Edalati, Masoud

doi:10.1080/1120009x.2018.1525120

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…Thus, they probably overestimate the rates of resistance among patients with uncomplicated UTIs [ 1 ]. There are, however, several studies that mainly focused on community-acquired uropathogens in Iran and similarly reported high rates of resistance to TMP-SMX (32%–76%) [ 11 , 20 – 25 ] and ciprofloxacin (32%–48%) [ 11 , 20 , 22 , 23 ] among E. coli strains. The high resistance rates among community-acquired uropathogenic E. coli strains in our study and most of the previous studies in Iran could be at least partly attributable to the high level of antibiotic consumption in the country, with 38.78 defined daily doses of antibiotic per 1000 people [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance among Community-Acquired Uropathogens in Mashhad, Iran

Vakilzadeh

Heidari

Mehri

et al. 2020

Journal of Environmental and Public Health

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Background. Antimicrobial resistance among community-acquired uropathogens is an emerging concern over the past decades that warrants a continuing reevaluation of the appropriateness of recommended empiric antimicrobial regimens for treatment of urinary tract infections (UTIs). Aims. To describe the microbial spectrum and resistance profile of community-acquired uropathogens and predictors of isolation of resistant strains. Methods. Between October 2017 and June 2019, individuals who visited the outpatient clinics for diagnosis of UTIs or screening of asymptomatic bacteriuria were included in the study if they were tested for urine culture in one of the three main medical diagnostic laboratories of Mashhad, Iran. The standard disk diffusion antimicrobial susceptibility testing was used, with the Clinical and Laboratory Standards Institute (CLSI) threshold cutoffs for susceptibility of isolated uropathogens. Results. Three hundred thirty cases were included with a median age of 47 years. Two hundred seventy-six (83.6%) were female. The most common isolated uropathogens were Escherichia coli in 201 (60.9%) cases and Klebsiella species in 46 (13.9%) cases. E. coli isolates showed the highest rates of susceptibility to nitrofurantoin (89.3%), cefixime (75%), and gentamicin (72.4%). Exposure to antibiotics in the past 3 months was a predictor of resistance to ciprofloxacin (OR: 2.8, 95% CI: 1.33–6.28), and older age was a predictor of resistance to TMP-SMX (OR: 2.1, 95% CI: 1.07–3.97) among E. coli isolates. Conclusion. E. coli and Klebsiella species accounted for about two-thirds of community-acquired uropathogens. In regard to the high susceptibility rates, nitrofurantoin was identified as the first-choice agent for empiric treatment of community-acquired cystitis, while cefixime and gentamicin might be the second-choice alternatives. Ciprofloxacin and TMP-SMX, on the other hand, cannot be considered appropriate agents for empiric therapy of community-acquired UTIs, particularly in those who had exposure to antibiotics in the past 3 months and the elderly.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance among Community-Acquired Uropathogens in Mashhad, Iran

Vakilzadeh

Heidari

Mehri

et al. 2020

Journal of Environmental and Public Health

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“…Another study in Italy showed that the female-to-male ratio was higher in the 15-29 years old patients (F/M ¼ 13.5) and lower in the children under 14 years old (F/M ¼ 1.4) [26]. In a study conducted in Isfahan, Iran, the highest F/M ratio was in the patients 15-30 years old (F/M ¼ 63.3) and the lowest was in the children under 2 years old (F/M ¼ 2.6) [27].…”

Section: Discussionmentioning

confidence: 96%

Antimicrobial resistance patterns of uncomplicated urinary tract infection among inpatients at the Mousavi education & treatment center, Zanjan, Iran

Afkari Atigh,

Islambulchilar,

Pourmirza

2023

Reviews and Research in Medical Microbiology

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Purpose: Urinary tract infection (UTI) is a very common bacterial infection caused by a wide variety of pathogens. Bearing in mind that the common pathogens that cause the infection are well known, it remains imperative to study their antibiotic resistance profile to be acquainted with the proper antibiotics to be administered and also to prevent the resistance to antibiotics. This study aims to determine the prevalence of uropathogens and antibiotic resistance patterns. Methods: This descriptive and retrospective cross-sectional study was conducted on 267 patients with UTI who were admitted to Mousavi Hospital in Zanjan, Iran, for 1 year. Patient records, urine tests, antibiotic susceptibility tests, and prescribed antibiotics were collected from laboratory archives and medical records. Results: In total, 267 urine samples were studied, the majority of them (78.7%) were acquired from a community setting. Most of them were female. The most common uropathogens were Escherichia coli (86.8%), Klebsiella (3%), Pseudomonas aeruginosa (2.2%), Staphylococcus aureus (2.2%), Staphylococcus epidermidis (2.2%). The isolated microorganisms were mostly resistant to cefixime (36%), ceftriaxone (31.1%), and ciprofloxacin (29.2%). Conclusion: We recommended that ceftriaxone, which was the first-line treatment choice in our conclusive study, should no longer be administered experimentally and used only upon detection of the bacteria and antibiogram testing.

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“…Urinary tract infection (UTI) is described as the health condition that has association between clinical signs and symptoms and detection of pathogenic microorganisms in the urine, bladder, urethra, kidney and prostate [12] . UTIs are the second most common bacterial infection affecting individuals of different ages worldwide [13] . Globally, an estimated 50% of women have UTIs at least once in their lifetime and UTIs are particularly more common in those aged 16-64 years [13,14] .…”

Section: Discussionmentioning

confidence: 99%

“…UTIs are the second most common bacterial infection affecting individuals of different ages worldwide [13] . Globally, an estimated 50% of women have UTIs at least once in their lifetime and UTIs are particularly more common in those aged 16-64 years [13,14] . Prevalence of UTIs is very low among boys but can be observed in the first year of life particularly in those with anatomical or functional abnormalities [15] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiotic Susceptibility Pattern of Enterococcus Spp. Isolated from Urine Samples

SujonAli,

AshiqurRahman,

Islam

et al. 2023

MMR

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Enterococci are the most common cause of healthcare-associated urinary tract infections. Enterococcus spp. were isolated from each of Urine and differences for Enterococcus contamination in urine were determined. Because of its unimportant commensals, Enterococci have developed into diverse, deadly diseases due to the routinely prescribed antibiotics for the treatment of nosocomial UTIs are less effective, the developing antibiotic resistance is concerning. This study aimed to determine the prevalence and antibiotic susceptibility patterns of different enterococcal species isolated from urine samples and to observe the prevalence of microbes in urine samples among the different types of patients. The frequency of enterococci isolation from hospitalized patients' urinary tract has risen. This cross-sectional study was conducted from March 2021 to December 2021 at the Department of Microbiology, AMZ Hospital Dhaka, Bangladesh. A total of 439 urine samples were collected and 96 (21.87%) samples showed growth of different isolates, in growth isolates 29 (30.20%) samples were Enterococcus spp. In this study, the sample was sensitive against Linezolid (95.55%), Vancomycin (89.67%), Penicillin (68.98%), Gentamycin (68.96%), Imepenum (55.17%). From our study revealed that different strains of Enterococcus spp. are resistant to drugs at different rates.

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Common microbial causes of significant bacteriuria and their antibiotic resistance pattern in the Isfahan Province of Iran

Cited by 10 publications

References 31 publications

Antimicrobial Resistance among Community-Acquired Uropathogens in Mashhad, Iran

Antimicrobial Resistance among Community-Acquired Uropathogens in Mashhad, Iran

Antimicrobial resistance patterns of uncomplicated urinary tract infection among inpatients at the Mousavi education & treatment center, Zanjan, Iran

Prevalence and Antibiotic Susceptibility Pattern of Enterococcus Spp. Isolated from Urine Samples

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