Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Uutela, Pauliina; Passweg, Jakob; Weiger, Roland; Waltimo, Tuomas; Mauramo, Matti

doi:10.1111/ejh.13209

Cited by 12 publications

(29 citation statements)

References 35 publications

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“…Similarly to our recent previous study, also in this study periodontitis was determined indirectly by measuring radiological attachment loss from panoramic radiographs [28]. This method was selected to avoid bacteremia and to keep the dental visits as short as possible for the severely ill patients immediately prior to the transplantation.…”

Section: Discussionmentioning

confidence: 99%

Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation

et al. 2019

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IntroductionHaematopoietic stem cell transplantation (HSCT) recipients are at increased risk for severe infections. This study examined the associations of common oral infections with survival and infectious complications in HSCT recipients.Materials and methodsAll autologous and allogeneic HSCT recipients transplanted in the University Hospital of Basel, Switzerland, between 2008 and 2016 and referred to oral infection control pre-HSCT were included in this retrospective case-control study. All patients had a clinical and a panoramic radiological dental examination taken immediately prior to HSCT. Presence of acute or chronic oral foci of infections, decayed, missing or filled tooth index (DMFT) and radiological attachment loss (RAL) were examined. Survival and infections of the subjects were followed up for 6 months post-HSCT.ResultsAltogether 341 allogeneic and 125 autologous HSCT recipients were included in the study. Within 6 months post-HSCT, 47 (14%) of the allogeneic and 4 (3%) of the autologous recipients died. Oral foci of infections (acute or chronic), DMFT or periodontitis pre-HSCT were not associated with survival 6 months post-HSCT. Oral foci of infections were also not associated with hospital treated infectious diseases or blood culture positive bacteremia during the 6 month follow-up period. Untreated oral foci of infections were not associated with survival or severe infectious complications within 6 months post-HSCT.ConclusionThe results of this study suggest that radical dental interventions to chronic oral infections could be postponed until post-HSCT.

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Section: Discussionmentioning

confidence: 99%

Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation

et al. 2019

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“…[38][39][40] Clinical and radiological oral and dental examinations were car- Stimulated salivary flow rate measurement was conducted at each appointment as described in our previous studies. 28,41 SSFR ≤ 0.7 mL/min was defined as hyposalivation, and SSFR ≤ 0.3 mL/min as severe hyposalivation. 13 Oral and dental examination, including decayed, missing, filled teeth (DMFT) index according to WHO, was performed.…”

Section: Patients and Me Thodsmentioning

confidence: 99%

“…vious study, was used to keep the dental visits as short as possible and to avoid bacteraemia and infectious complications prior to the HSCT 41. Some of the HSCT recipients have received therapies for their underlying diseases already for years, which could have influenced the oral health pre-HSCT.…”

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confidence: 99%

“…It should be noted that the method of determining the presence of periodontitis is inaccurate and can lead to underestimation of the effect of periodontitis on post-HSCT comorbidity and survival, and these results must be observed with caution. This RAL based manner, used also in our previous study, was used to keep the dental visits as short as possible and to avoid bacteraemia and infectious complications prior to the HSCT 41. Some of the HSCT recipients have received therapies for their underlying diseases already for years, which could have influenced the oral health pre-HSCT.…”

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confidence: 99%

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Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Uutela

Passweg

Gerull

et al. 2019

European J of Haematology

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Objectives Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. Methods Two hundred and sixty nine adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with 6‐month survival and the progression of the oral disorders within 2 years were examined. Results Forty HSCT recipients (14.8%) deceased within 6 months post‐HSCT. Among the deceased recipients, hyposalivation and caries were more common pre‐HSCT than in recipients who survived over 6 months (P < 0.05). HSCT recipients with hyposalivation pre‐HSCT had higher risk of death (HR: 1.90, 95% CI:1.00‐3.60; P = 0.044) within 6 months post‐HSCT compared with recipients without hyposalivation. Hyposalivation pre‐HSCT was associated with a higher DMFT index score (P < 0.05) and a smaller number of teeth (P < 0.005) 24 months post‐HSCT in comparison with those without hyposalivation. Conclusions Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post‐HSCT.

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“…Hypoplastic enamel changes, delayed tooth eruption, endogenous changes in tooth color, as well as changes in the development of the roots of primary and permanent teeth are the most commonly occurring anomalies [4][5][6][7].…”

Section: сажетакmentioning

confidence: 99%

Oral changes in patients before and after transplantation of solid organs and hematopoietic stem cells

et al. 2021

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Introduction/Objective. The aim of this paper is to point out the prevalence and severity of oral diseases in patients in the period before and after the transplantation of solid organs and hematopoietic stem cells. Methods. MEDLINE literature search was done via PubMed. Results. The development and improvement of transplantation medicine in specialized centers lead to an increasing number of patients, both adults and children, with transplanted solid organs and hematopoietic stem cells. Despite the success of therapy, numerous changes and complications can be observed on other organs in patients undergoing transplantation of solid organs and hematopoietic stem cells in the pre and post-transplant phase. Systemic diseases and conditions related to organ and cell transplantation, which are accompanied by numerous oral manifestations. The most common oral changes are gingival enlargement, desquamation of the oral epithelium, very painful ulcerations, polypoid and granulomatous changes in the oral mucosa, hard dental tissues with frequent complications, developmental anomalies of teeth in younger children, and in the later stage also the occurrence of oral cancer. After transplantation of solid organs and hematopoietic changes in the oral cavity and other organs occur depending on the patient?s post- transplantation period as well as on the applied immunosuppressive therapy. Conclusion. Oral changes development pre and post transplantation of solid organ and hematopoietic stem cells points to the importance of timely and good cooperation between the dentist and the doctor who treats the underlying disease.

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Common oral diseases in allogeneic haematopoietic stem cell transplantation (HSCT) recipients pre‐HSCT

Cited by 12 publications

References 35 publications

Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation

Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation

Common oral diseases, hyposalivation and survival post‐HSCT, a longitudinal study

Oral changes in patients before and after transplantation of solid organs and hematopoietic stem cells

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