Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes

Abstract

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.

The relationship between thyroid hormone levels, insulin resistance and body mass index, in patients with subclinical hypothyroidism andeuthyroid patients

“…Three different tools were used to determine insulin resistance; Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI) [12] and Atherogenic Index of Plasma (AIP) [13].…”

Aggregation of type-2 diabetes, prediabetes, and metabolic syndrome in German couples

“…Little is known about spousal concordance for prediabetes and for the metabolic syndrome. Apart from few studies from Asia and the UK, the association of prediabetes in married couples has not been paid much attention 14 – 16 . Studies from Korea and Japan found spousal concordance for the metabolic syndrome 14 , 17 .…”

Prediabetic risk factors among children and adolescents with obesity

“…Obesity at an early age is linked with increase the chance to type 2 diabetes and may be lead to a lower life expectancy (Morandi & Maffeis, 2014). The same factors that lead to increase the risk of type 2 diabetes also lead to increase the risk of prediabetes: obesity, a large waist, a high-fat diet (including red meat, processed meat, and sugar-sweetened beverages), physical inactivity, advanced age, race, family history, gestational diabetes(GD), polycystic ovary syndrome, obstructive sleep apnea, and tobacco use (Hsu et al, 2021). Diabetes and cardiovascular disease are more likely in those with prediabetes than in those who do not have it (Care & Suppl, 2019).…”