“…Histamine is secreted by mast cells during exposure to allergens, and the level of circulating histamine rises during prolonged hyperventilation (Kontos et a1 1972). Wilson and colleagues demonstrated (1982) that even in the absence of an immediate episode of bronchospasm, a reac-Box 3.3 Food sensitivity and its relation to bronchial conditions A summary of the evidence relating food sensitivity to asthma and other bronchial conditions is given below: 0 Avoidance by lactating mothers of milk, eggs, fish, and nutsand avoidance by the infant (up to 12 months) of the same foods plus soy, wheat, and orangesreduced allergic disease (including asthma) in 58 cases compared with 62 controls (Spector 1991) In adults who have asthma the prevalence of food allergy in one double-blind, placebo controlled study was 2%, and in children 6.8%. This last effect is especially relevant to asthmatics, but can affect anyone to some degree, adding to breathing difficulty.…”