Common variable immunodeficiency-associated myelitis

Neurologic Complications of Common Variable Immunodeficiency

“…In general, however, the benefit of higher or more frequent dosing of IgG for viral illnesses associated with CVID is not well investigated. Multiple other factors, such as environmental (43) Adenovirus meningoencephalitis (2) [25] Bacterial meningitis (22) [1,[26][27][28][29] BKV encephalitis and optic neuritis (1) [30] CMV encephalomyelitis (1) [31] Echovirus meningoencephalitis (1) [25] Histoplasmosis (1) [28] HSV encephalitis (3) [9] Mumps encephalitis (1) Poliovirus (1) [32] Progressive Multifocal Leukoencephalopathy (6) [3][4][5][6][7][8] Toxoplasma encephalitis (2) [33,34] Varicella angiitis (1) [35] Varicella zoster encephalitis (1) [1] West Nile meningitis (1) [36] Autoimmune/Inflammatory (13) optic neuritis (1) [37] myelitis (4) [10,11,38,39] limbic encephalitis (1) [12] Guillian Barre Syndrome (1) [40] granulomatous mass (4) [41][42][43][44]45] chronic inflammatory demyelinating polyneuropathy (1) [39] acute disseminated encephalomyelitis (2) [14,46] Unknown etiology (10) encephalopathy (4...…”

Longitudinally extensive transverse myelitis: a rare association with common variable immunodeficiency

“…In relation to neurological involvement in CVID, infliximab has had mixed results. Reports suggest that a synergistic effect of intravenous immunoglobulin and infliximab improves neuroimaging appearances as well as systemic features such as fever, night sweats and lymphadenopathy whilst having no effect clinically on neurological deficits 11. Furthermore, a recent case of recurrent myelitis in CVID showed a good response to once weekly subcutaneous immunoglobulin with remission at 3-year follow up 12…”

Recurrent myelitis in common variable immunodeficiency successfully managed with high-dose subcutaneous immunoglobulin

“…Clinicians must consider checking for vitamin E deficiency in all CVID patients with evidence of an enteropathy, as early detection and appropriate treatment may avoid arrest or reverse the neurological degenerative disease 6. In CVID, myelitis has been reported only in a few cases 5 7. Kumar et al 7 recently described a patient in whom the neurological involvement was supposed to be linked to granulomatous disease.…”

“…In CVID, myelitis has been reported only in a few cases 5 7. Kumar et al 7 recently described a patient in whom the neurological involvement was supposed to be linked to granulomatous disease. She was treated with infliximab that resolved systemic symptoms (fever and night swears) and reduced the thoracic lymphadenopathy.…”