Common variable immunodeficiency in a horse with chronic peritonitis

Abstract

Summary This report describes the clinical progression of a Quarter Horse filly with common variable immunodeficiency (CVID). Equine CVID is a primary immunodeficiency in which affected animals are unable to mount an appropriate antibody response and suffer recurrent bacterial infections. The filly in this report had a history of chronic respiratory tract infections but presented for assessment of poor weight gain and was diagnosed with Actinobacillus equuli peritonitis.

CVID in a horse with chronic peritonitis: Case review and overview of other immunodeficiencies

“…As was well described in the CVID case presented (Tennent‐Brown et al . 2010), if foals or horses have recurrent infections, diagnostics to assess whether an underlying immunodeficiency is present are critical.…”

“…In the companion article, Tennent‐Brown et al . (2010) diagnosed a 2‐year‐old filly, with an 8 month history of recurring respiratory signs, with combined variable immunodeficiency (CVID) syndrome.…”

“…In the companion article (Tennent‐Brown et al . 2010), the authors provide excellent information on CVID in horses and humans.…”

“…In the companion article, Tennent-Brown et al (2010) diagnosed a 2-year-old filly, with an 8 month history of recurring respiratory signs, with combined variable immunodeficiency (CVID) syndrome. In addition to the underlying immunodeficiency, the authors focused predominantly on diagnosing and managing the peritonitis.…”

Expression of essential B cell development genes in horses with common variable immunodeficiency

“…Our laboratory diagnosed the index case and further characterized CVID in horses, which manifests as late-onset recurrent bacterial infections, hypo- or agammaglobulinemia, progressive B cell lymphopenia or depletion, and poor response to protein (tetanus toxoid) vaccination (Flaminio et al 2002; Pellegrini-Masini et al 2005; Flaminio et al 2009; Tennent-Brown et al 2010). Affected patients are unrelated adult horses (average age 10.7 ± 4.4 years) of both sexes, many different breeds, and living in distinct parts of the country.…”