Common variant rs7579169 is associated with preeclampsia in Han Chinese women

Abstract

ABSTRACT. As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancyinduced hypertension in Europeans. In this study, we examined whether the SNP rs7579169 is associated with the susceptibility to preeclampsia through a case-control research model in Han Chinese women. Genotypes of 145 patients with preeclampsia and 150 healthy pregnant subjects were identified by direct sequencing. The correlation between the rs7579169 genotype and the susceptibility to preeclampsia was evaluated using an unconditional logistic regression model. Although there were no differences of having the rs7579169 SNP between early onset and late onset preeclampsia, patients carrying the CT or TT genotype were more likely to develop preeclampsia than those carrying the CC genotype (CT vs CC: OR = 1.76, 95%CI = 1.07-2.87, P < 0.05; TT vs CC: OR = 5.03, 95%CI = 1.99-12.73, P < 0.05; CC vs CT + TT: OR = 2.05, 95%CI = 1.27-3.30, P < 0.05). In conclusion, although no differences of the rs7579169 SNP were identified between the early onset and late onset preeclampsia groups, we found that the CT or TT genotype and the CT+TT genotype were significantly associated with an increased risk of preeclampsia in Han Chinese women.

Genetic and non‐genetic risk factors for pre‐eclampsia: umbrella review of systematic reviews and meta‐analyses of observational studies

“…One study identified two loci (rs7579169 and rs12711941) near the inhibin beta B gene that satisfied the genome‐wide significance threshold, but the results could not be replicated in two cohorts from Norway and Finland. Subsequent case–control studies in European and Chinese women have shown a significant association between the SNP rs7579169 and PE.…”

Research Article Haplotype-based case-control study of calpain (CAPN2) gene and hypertensive disorders of pregnancy

“…Since HDP is thought to be induced by a two-step mechanism, the pathology of HDP likely originates in a background of placental dysfunction (Chen et al, 2017). Many causes of HDP have been reported, and HDP is believed to be a multifactorial genetic disorder (Guo et al, 2016). The main mechanisms involved in HDP are believed to include damage to endothelial cells, thrombotic tendencies, placenta dysfunctions, and oxygen deficiencies (Gu et al, 2017).…”

“…Among calpains with a nonspecific catalytic subunit, two types (μ-calpain and m-calpain) have been the subjects of advanced functional analysis (Goll et al, 2003). Notably, μ-calpain and m-calpain share the same regulatory subunit, CAPNS1, but differ in their catalytic subunit, with μ-calpain employing CAPN1, and m-calpain employing CAPN2 (Guo et al, 2016).…”