Common variants in human CRC genes as low-risk alleles

The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma

“…12,13,17 Third, the MLH1 rs1799977 AG/GG genotype harbors prognostic relevance also in disease models other than lymphoma, including acute lymphoblastic leukemia, solid tumors, and inflammatory bowel disease. [40][41][42][43][44][45][46][47] The cross-validation approach of the current study documents that the MLH1 rs1799977 genotype is an independent prognostic factor retaining its value in 2 DLBCL series treated at different institutions using similar therapeutic strategies. This observation suggests that the prognostic value of MLH1, although detected retrospectively, appears to be independent of a potential bias because of patient referral or patient management at a single center.…”

MLH1 Polymorphisms and Cancer risk: a Meta-analysis Based on 33 Case-control Studies

“…There are 20 case-control studies concerning -93G>A polymorphism (Ito et al, 1999;Deng et al, 2003;Park et al, 2004;Chen et al, 2005;Lee et al, 2005;Beiner et al, 2006;Song et al, 2006;Raptis et al, 2007;An et al, 2008;Harley et al, 2008;Koessler et al, 2008;Scott et al, 2008;Tulupova et al, 2008;Campbell et al, 2009;Shi et al, 2010;Shih et al, 2010;van Roon et al, 2010;Lacey et al, 2011;Lo et al, 2011;Whiffin et al, 2011) and 18 studies for I219V (Mathonnet et al, 2003;Listgarten et al, 2004;Lee et al, 2005;Mei et al, 2006;Song et al, 2006;Raptis et al, 2007;An et al, 2008;Capella et al, 2008;Smith et al, 2008;Campbell et al, 2009;Conde et al, 2009;Joshi et al, 2009;Nejda et al, 2009;Tanaka et al, 2009;Langeberg et al, 2010;Picelli et al, 2010 polymorphisms are summarized in Table 1. Most studies indicated that the genotypes distribution in the controls was consistent with Hardy-Weinberg equilibrium except for six studies for -93G>A (Park et al, 2004;Beiner et al, 2006;An...…”

“…For -93G>A, the magnitude of the summary ORs has been undergoing a trend of an increasingly stable effect as postulated (in random effect model, summary ORs for Asian Pacific Journal of Cancer Prevention, Vol 13, 2012 905 DOI:http://dx.doi.org/10.7314/APJCP.2012.13.3.901 MLH1 Polymorphisms and Cancer risk: a Meta- (Langeberg et al, 2010;Picelli et al, 2010), which reported MLH1 I219V associated with an increased risk of lung cancer in the dominant model. The funnel plots of both two polymorphisms seem symmetrical, suggesting there's no publication bias.…”

MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population

“…Similarly, Liu et al (1995) and Peng et al (2015) suggested that MLH1 -93G> A, I219V and G39E polymorphisms were not associated with neither adenomatous polyps nor colorectal polyps. Also, Picelli et al (2010) found that MLH1 I219V polymorphism increased the risk of CRC risk; however, the association did not reach statistical significance.…”