Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk

Akdi, Abdelmounaim; Pérez, Gisselle; Pastor, Susana; Castell, J; Biarnés, Josefina; Marcos, Ricard; Velázquez, Antonia

doi:10.1089/thy.2010.0384

Cited by 16 publications

(17 citation statements)

References 27 publications

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“…To further assess the association between TC risk and rs6983267G, we performed meta-analysis of our multi-ethnic study and all previously published data from populations of European ancestry from the US, Spain, Italy and Poland (Akdi et al 2011; Cipollini et al 2013; Wokolorczyk et al 2008). Supplementary Table 2 shows previously reported data in these latter populations.…”

Section: Resultsmentioning

confidence: 99%

“…For example, we found that rs6983267G was associated with TC in the UK population and that it increased the association with disease using both recessive and allelic models (Jones, et al 2012). Studies in the US, Italian and Spanish cohorts have not, however, been able to replicate an association between this 8q24 variant and TC (Akdi, et al 2011; Cipollini, et al 2013; Neta, et al 2012). …”

Section: Introductionmentioning

confidence: 92%

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The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

Sahasrabudhe

Estrada

Lott

et al. 2015

Endocrine-Related Cancer

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The G allele of the rs6983267 single nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in thyroid cancer susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3,067 cases and 8,575 controls. We detected significant associations between rs6983267G and thyroid cancer in the British Isles (Odds Ratio, OR= 1.19, 95% confidence interval, CI: 1.11–1.27, P= 4.03 × 10−7), Japan (OR= 1.20, 95% CI: 1.03–1.41, P= 0.022) and a borderline significant association of similar effect direction and size in Colombia (OR= 1.19, 95% CI: 0.99–1.44, P= 0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5,484 cases and 12,594 controls, confirmed the association between rs6983267G and thyroid cancer (P= 1.23 × 10−7, OR= 1.13, 95% CI: 1.07–1.18). Our results therefore support the notion that rs6983267G is a bona fide thyroid cancer risk variant that increases the risk of disease by ~13%.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

Sahasrabudhe

Estrada

Lott

et al. 2015

Endocrine-Related Cancer

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“…Wide range of genetic factors were reported in thyroid cancer susceptibility (Akdi et al, 2011;Schlumberger et al, 2011). The DTC is the most common malignancy of the thyroid gland and involves some molecular ethiological parameters such as; point mutations in proto-oncogenes of BRAF V600E, KRAS, RET, functional genes of MTHFR, MDR1 and epigenetic alterations of several tumor suppressor gene abnormalities (Jasim et al, 2011;Jin et al, 2011;Ozdemir et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C＞T Gene Polymorphism in Differentiated Thyroid Cancers

Özdemir¹,

Uludağ²,

Sılan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Then, several authors conducted hypothesis-driven case-control studies to verify specific single-nucleotide polymorphisms (SNP) within SR8q24 in relation to DTC. Positive associations were found among Polish (3) and British (4), whereas lack of associations was found in Spanish (5) and Texans (6). In summary, the findings were poorly reproducible also because a limited statistical power of some studies.…”

Section: Introductionmentioning

confidence: 94%

Risk of Differentiated Thyroid Carcinoma and Polymorphisms within the Susceptibility Cancer Region 8q24

Cipollini¹,

Figlioli

Garritano

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Genome-wide association studies have shown that the 8q24 region harbours multiple independent cancer susceptibility loci and it was also defined as the "susceptibility cancer region." Thus, it could be hypothesized that genetic variants within this region could play a role in the risk of differentiated thyroid carcinoma (DTC).Methods: Six single-nucleotide polymorphisms within 8q24 were analyzed, previously associated with the risk of cancer (i.e., rs6983267, rs1447295, rs10808556, rs7000448, rs13254738, and rs13281615) in a population of 1,250 patients affected by DTC and 1,250 controls from Central and Southern Italy.Results: A strong association between smoking habit and risk of DTC was found [OR, 1.63; 95% confidence interval (CI), 1.39-1.91; P < 10

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Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk

Abstract: In this study, we show for the first time that the TG gene is a susceptibility factor for thyroid cancer. Although these conclusions are based on a large population, additional studies are warranted to support these data.

Cited by 16 publications

References 27 publications

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C＞T Gene Polymorphism in Differentiated Thyroid Cancers

Risk of Differentiated Thyroid Carcinoma and Polymorphisms within the Susceptibility Cancer Region 8q24

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