Common Warts Treatment by Intralesional (60,000 Versus 120,000) IU of Vitamin D3, Comparative Study

doi:10.37506/mlu.v21i1.2424

Cited by 1 publication

(2 citation statements)

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“…Amin et al compared cryotherapy with intralesional vitamin D3 (5 mg/ml) for warts on the hands and feet and showed similar efcacy for both modalities [10]. In another study, Ihsan Mahmoud and Ayyash used 60,000 and 120,000 IU of intralesional vitamin D3 for common warts and found both efective without any signifcant diference [11]. Additionally, Kumar and Brar demonstrated that 600,000 IU intralesional vitamin D3 was safe and efective for the treatment of palmoplantar warts [17].…”

Section: Discussionmentioning

confidence: 99%

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Topical Calcipotriol for the Treatment of Cutaneous Warts: An Assessor‐Blind Randomized Placebo‐Controlled Trial

Kazeminejad

Bodaghi

Hajheydari

et al. 2023

Dermatologic Therapy

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Background. Cutaneous warts are common epidermal proliferations caused by human papillomavirus (HPV). We aimed to determine the safety and efficacy of topical calcipotriol for the treatment of cutaneous warts. Methods. This assessor-blind randomized placebo-controlled trial included 56 patients with cutaneous warts referred to a dermatology clinic from January 21 to March 20, 2020. Patients were randomized into two groups (n = 28). One group received calcipotriol 0.05% ointment twice a day on the lesions with a uniform thickness of 1 mm, and the other group received a placebo. The duration of treatment was twomonths, which continued for another two months if resolution did not occur. The primary outcome was complete response to treatment evaluated four months after the initiation of therapy. Secondary outcomes were the number and size of warts assessed at 1, 2, and 4 months and adverse events, including erythema, pruritus, burning sensation, and scaling. Results. Patients in both groups were comparable regarding previous treatment, underlying disease, and disease duration. However, patients in the control group were older. Also, a higher proportion of patients in the calcipotriol group were male and had warts on their palms and toes. Moreover, a higher percentage of controls had moderate disease. The mean number and the size of lesions did not differ between groups before intervention; however, both were significantly lower in the calcipotriol group than in controls at 1st, 2nd, and 4th months. In addition, complete response to treatment was significantly higher in the calcipotriol group (85.7% vs. 16%; P < 0.001 ). On the other hand, the frequency of adverse events was not different between groups ( P = 0.352 ). Conclusions. Calcipotriol can be considered a safe and effective treatment option for cutaneous warts. Trial Registration: This trial is registered with IRCT20170818035762N2, available at https://www.irct.ir/trial/45716.

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Section: Discussionmentioning

confidence: 99%

“…Tis leads to the modulation of innate immunity [7]. Intralesional vitamin D has been shown to be safe and efective for the treatment of warts [8][9][10][11]. Very few studies have also demonstrated the efcacy of topical vitamin D derivatives in this regard, including a case report and a study on 17 patients [12,13].…”

Section: Introductionmentioning

confidence: 99%