Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease

Southerland, Janet H.; Taylor, George W.; Moss, Kevin; Beck, James D.; Offenbacher, Steven

doi:10.1111/j.1600-0757.2005.00138.x

Cited by 172 publications

(163 citation statements)

References 164 publications

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“…Thus the effects of acute inflammation on hMSC responses could be quite different from the effects of chronic inflammation. The latter is present systemically during aging and in conditions such as obesity, diabetes, rheumatoid arthritis, and osteoporosis (32,33). Mineralization of soft tissues, such as ligaments and the vasculature, is associated with some of these conditions, and our data suggest one mechanism through which this could occur.…”

Section: Discussionmentioning

confidence: 88%

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

Ferreira

Porter

Wehling

et al. 2013

Journal of Biological Chemistry

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Background:The effects of inflammation upon the biology of human mesenchymal stem cells are poorly understood. Results: IL-1␤ provoked massive hydroxyapatite deposition by inhibiting ectonucleotide pyrophosphatase. Cells did not express typical markers of osteoblasts or other mesenchymal lineages. Conclusion: Inflammation promotes mineralization by a novel mechanism. Significance: These data provide new insights into cytokine effects on mineralization of soft tissues.

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Section: Discussionmentioning

confidence: 88%

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

Ferreira

Porter

Wehling

et al. 2013

Journal of Biological Chemistry

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“…The dose-response relationship results support the fact that increasing soft drink intake was associated with the risk for PD, regardless of whether the CPI or LA index was used, after adjusting for hyperglycaemia and other relevant confounding factors, although the causal relationship still needs to be verified. While the mechanism linking soft drink consumption and PD is not known, it is possible that oxidative stress (6)(7)(8)4,23) or bone mineralization (24)(25)(26)(27)(28) , either alone or in combination, is involved. More data will be required to verify this.…”

Section: Impact Of Soft Drinks On Periodontal Diseasementioning

confidence: 99%

“…For instance, glucose-containing carbonated soft drinks increase carbonyl stress burden (3) , which, in turn, may result in a decrease in antioxidant concentration in oral saliva (4) and enhance oxidative nitration in association with the inflammatory reaction (5) . From the biological viewpoint, the inflammatory reaction caused by such oxidative stress is highly associated with systemic diseases, such as metabolic syndrome, diabetes, hypertension, asthma and periodontal disease (PD) (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) . Oxidative stress (2,3,6,8,9,(13)(14)(15) pertaining to PD may be mediated through advanced glycation end-products that are created through non-enzymatic pathways from monosaccharide substances, dicarbonyls originating from the Maillard reaction, sugar self-oxidation and other molecular pathways (16,17) .…”

mentioning

confidence: 99%

A population-based study on the association between the intake of soft drinks and periodontal disease in Taiwanese adults aged 35–44 years (KCIS no. 33)

Fann¹,

Lai²,

Chiu³

et al. 2015

Public Health Nutr.

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Objective: To elucidate the association between the intake of soft drinks and periodontal disease (PD) among Taiwanese middle-aged adults. Design: The cross-sectional design was employed to assess a dose-response relationship between the intake of soft drinks and PD after controlling for relevant confounding factors, with adjusted odds ratios obtained from a multivariate logistic regression model. Setting: Keelung Community-based Integrated Screening (KCIS) programme, Keelung, Taiwan. Subjects: Participants (n 10 213) aged 35-44 years who had undergone oral checks for PD between 2005 and 2009. Results: A dose-response relationship between the intake of soft drinks and elevated risk for PD defined by community periodontal index ≥3 (the current status of PD) was noted (P = 0·02 by trend test). Compared with infrequent intake of soft drinks (≤2 times/week), the adjusted OR increased from 1·05 (95 % CI 0·92, 1·20) for the frequency of 3-4 times/week to 1·17 (95 % CI 1·03, 1·34) for the frequency of ≥5 times/week. A similar trend (P < 0·01) was also observed for PD defined by loss of attachment ≥1 (representing the long-term cumulative gum damage due to PD). Conclusions: A dose-response relationship between the intake frequency of soft drinks and PD was observed in Taiwanese middle-aged adults. Such evidence could be used in health promotion to support reductions in soft drink intake.

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“…The presence of conditions that cause reduction in salivary flow, including diabetes mellitus, drug usage, poor nutrition and advanced age, for instance, may also cause oral microbiota disequilibrium. [9][10][11][12] However, simple attitudes such as the removal of the denture during the night and its correct hygiene with the daily usage of disinfecting solutions are mentioned in the literature as effective in the prevention and treatment of denture stomatitis. 4,[13][14][15] Thus, many studies have been performed with the objective of evaluating the efficiency of different disinfecting solutions in the control of Candida genus yeasts, searching for a disinfecting solution that would present excellent antimicrobial activity without harming the patient's health or causing alterations in the physical-structural characteristics of dentures.…”

Section: Introductionmentioning

confidence: 99%

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

et al. 2009

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The purpose of this study was to evaluate the effect of 5% sodium bicarbonate on the adherence of Candida albicans to thermally activated acrylic resin. Fifty 4 mm² specimens of acrylic resin were obtained using a metallic matrix. The specimens received chemical polishing, were sterilized and then immersed in Sabouraud broth, inoculated with Candida albicans standardized suspension. After 24 hours of incubation at 37°C, the specimens were divided into four groups according to the substance used for disinfection (5% sodium bicarbonate, 0.12% digluconate chlorhexidine, vinegar and Corega Tabs). A control group was included, in which distilled water was used. The adhered microorganisms were dispersed, diluted and plated onto culture media to determine the number of colony-forming units (cfu/mL). The results were analyzed through the Mann-Whitney statistical test at the 5% level of significance. Only 0.12% digluconate chlorhexidine and 5% sodium bicarbonate presented a statistically significant difference (p = 0.0010 and p = 0.0156, respectively) compared to the control group, decreasing the number of cfu/mL. However, when the different disinfecting solutions were compared with each other, only 0.12% digluconate chlorhexidine presented a statistically significant difference in the reduction of cfu/mL. It was concluded that although 0.12% digluconate chlorhexidine was more effective in the reduction of Candida albicans adherence values to thermally activated acrylic resin, 5% sodium bicarbonate also proved to be a viable alternative.

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Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease

Cited by 172 publications

References 164 publications

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

A population-based study on the association between the intake of soft drinks and periodontal disease in Taiwanese adults aged 35–44 years (KCIS no. 33)

Effect of sodium bicarbonate on Candida albicans adherence to thermally activated acrylic resin

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