Residential segregation (RS) is a global phenomenon that has become an enduring and important topic in international academic research. In this review, using RS as the search term, 2520 articles from the period 1928–2022 were retrieved from the Scopus database and were visually analyzed using CiteSpace software. The results revealed the following: (1) The United States and its institutions have made outstanding contributions to RS research, while various scholars (e.g., Johnston, Massey, Forrest, Poulsen, and Iceland) have laid the foundation for RS research. (2) Mainstream RS research originates from three fields—psychology, education, and social sciences—while the trend of multidisciplinary integration is constantly increasing. (3) The research hotspots of RS include racial difference, sociospatial behavior, income inequality, mixed income communities, guest worker minorities, typical district segregation, occupational segregation, health inequalities, metropolitan ghetto, and migrant–native differential mobility. Furthermore, (4) gentrification, spatial analysis, school segregation, health disparity, immigrant, and COVID-19 have become new themes and directions of RS research. Future research should pay more attention to the impact of multi-spatial scale changes on RS as well as propose theoretical explanations rooted in local contexts by integrating multidisciplinary theoretical knowledge.