2016
DOI: 10.1016/j.cbpa.2016.06.013
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Communicating artificial cells

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Cited by 79 publications
(75 citation statements)
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“…Advances in the field of synthetic biology have brought us closer to the goal of designing artificial cells and cellular mimetic structures capable of complex biomanufacturing . Genetic circuitry can be harnessed in cell‐free environments in order to produce a variety of biological molecules . However, the synthesis of biological molecules with the diversity, efficiency, and spatial and temporal precision of cellular systems remains challenging.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Advances in the field of synthetic biology have brought us closer to the goal of designing artificial cells and cellular mimetic structures capable of complex biomanufacturing . Genetic circuitry can be harnessed in cell‐free environments in order to produce a variety of biological molecules . However, the synthesis of biological molecules with the diversity, efficiency, and spatial and temporal precision of cellular systems remains challenging.…”
Section: Discussionmentioning
confidence: 99%
“…[7,[67][68][69][70][71] Genetic circuitry can be harnessed in cell-free environments in order to produce av ariety of biological molecules. [72,73] However,t he synthesis of biological molecules with the diversity,e fficiency,a nd spatial and temporal precision of cellular systems remains challenging.T his challenge may be addressed through thoughtful engineering of synthetic membranes combined with strategic design of membrane architecture to allow for efficient, targeted, and specific fusion between vesicle compartments.W eexpect that by combining membrane design with improved DNAl inker chemistry, [15,16] biochemical product yield could be further improved.…”
Section: Discussionmentioning
confidence: 99%
“…For instance,a rtificial cells can serve as simplified models for the study of fundamental biological processes [24] or they may be simply regarded as cell-scale bioreactors forbiotechnology. [25] Communication among artificial cells or between artificial cells and their environment or natural cells [19,26] is seen as essentialf or the realization of potentialb iomedical applications, [27] for instance, in regenerative medicine andt issuee ngi-neering. Entirely new technologiesm ay becomep ossible through the realization of intelligent soft hybrid materials composed of consortia of artificial cells, which may be programmed to exhibit spatiotemporal patterns, [28,29] or molecularly programmeds oft robots composed of molecular sensors, processors, and actuators.…”
Section: Artificialcells and Their Applicationsmentioning
confidence: 99%
“…For instance, as imilars ender-receiver system was later employed to create artificial cells that were able to communicate with live bacterial cells, [32] somewhat remindingo fT uring's classical test for artificial intelligence. [19,33] Meanwhile, various groups reported communication between either identical or distinct types of artificial cells in aw ide variety of settings.E xamples include severals ender-receiver-types ystems, [32b, c] the realization of spatially distributed dynamics, [5,6,11] simple types of spatial differentiation in colloidal materials [8] and tissue-like droplet assemblies. [1] Recently,D NA-functionalized gel particlesw ere encapsulated within larger compartments as primitive mimics of eukaryotic cells with an ucleus and organelles, [9,12] and communication was demonstrated among particles within as ingle compartment, [9] and also between the eukaryotic cell mimics.…”
Section: Communicating Artificial Cellsmentioning
confidence: 99%
“…A direct consequence of compartmentalization is chemical and electrical signaling, which are key factors in imparting emergent properties to biological cells and tissues. Consequently, a mandatory feature of a protocell, and the success of its translation into a prototissue, is compartmentalization and communication between its multiple compartments23. As in natural cells, enclosing DNA, RNA, and proteins within protocells ensures protection from degradation24 while providing the required concentrations for optimal function2526.…”
mentioning
confidence: 99%