Communicating Genome Architecture: Biovisualization of the Genome, from Data Analysis and Hypothesis Generation to Communication and Learning

Abstract

Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the experimental and visualization techniques that have been developed recently which capture the three-dimensional interactions regulating how genes are expressed. We detail the challenges faced in integration of the data to portray the components and organization and their dynamic landscape. The goal is more than a single data-driven representation as interactive visualization for de novo research is paramount to decipher insights on genome organization in space.

Ink Art Three-Dimensional Big Data Three-Dimensional Display Index Prediction Model

“…e paper model is also an indispensable foundation for the simulation of the ink diffusion effect. Goodstadt et al proposed an automatic calculation model for water and ink particles based on the movement of paper elements and then applied them to the rendering of different parameters of the tree [12]. Vempati et al proposed using texture synthesis based on a probability model to render the 3D tree model.…”

Molecular Basis of the Function of Transcriptional Enhancers

“…The process requires the participation of hundreds of molecules, which form an extensive interaction network. Substantial progress was achieved recently in our understanding of the molecular processes that take place in the cell nucleus (e.g., see [1][2][3][4][5][6][7][8][9]). Novel techniques revealed multiple unexpected phenomena occurring in chromatin.…”