Communication and monitor of breast cancer signal in the pulse-output genetic circuit network

Wang, Xiang; Yuan, Guangqian; Wang, Xun; Zhao, Zhijin; Wang, Kan

doi:10.1007/s11432-014-5061-4

Cited by 1 publication

(1 citation statement)

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“…Chau used protein signalling circuits to produce spatial polarization in yeast by engineering circuits from components that can be self-organized into localized distributions [15]. We propose a genetic circuit network to realize the detection of breast cancer [16].…”

Section: Introductionmentioning

confidence: 99%

Genetic Circuit for the Early Warning of Lung Cancer using iBioSim

Wang¹,

Wang²,

Jiang³

et al. 2016

ITM Web Conf.

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Abstract. With the development of molecular biology and gene-engineering technology, gene diagnosis has been an emerging approach for modern life sciences. Biological marker, recognized as the hot topic in the molecular and gene fields, has important values in early diagnosis, malignant tumour stage, treatment and therapeutic efficacy evaluation. The design of markers detection genetic circuit system for lung cancer is presented as a new method to provide basis for early warning and therapy. The system consists of three singlemarker detection circuits and an integration circuit. The single-marker detection circuit provides an instantaneous low level when target marker's concentration reaches the threshold. The integration circuit uses gene and gate to complete the output data fusion from single-marker detection circuit through logic operations to finish the combined detection. All the structure is modelled and analyzed by iBioSim through the biochemical reactions of different gene circuits. The experimental result indicates that the whole lung cancer detection system can realize joint detection of tumor markers with good stability and sensitivity.

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Section: Introductionmentioning

confidence: 99%