Objective: To explore the application of CICARE communication mode in the communication between nurses and patients in the endocrinology nurses. Methods: A total of 40 internship nurses from the hospital endocrinology department from January 2018 to June 2018 were selected as the research objects. The survey nurses communicated with the patients in their daily work. They were divided into two groups, each with 20 cases. The observation group Based on the knowledge and trust model, the CICARE communication model was designed according to the characteristics of the hospital. The control group received traditional communication training and compared the training effects of the two groups. Result: After the training, the scores of communication ability between the two groups of nurses were significantly different. The scores of the observation group were higher than those of the control group (P<0.05). Before the training, there was no statistically significant difference in the scores of the nurses and patients in the two groups. (P>0.05), after the training, the score of the observation group was higher than that of the control group (P<0.05). The scores of satisfaction between the two groups and the family members were significantly different. The scores of the observation group were higher than those of the control group (P<0.05). Conclusion: The CICARE communication mode is applied to the communication training of nurses and patients in the endocrinology internship nurses, which can significantly improve the clinical communication ability of nurses and improve the satisfaction of patients and their families. It is worthy of promotion and application.