Communication in Fungi

Cottier, Fabien; Mühlschlegel, Fritz A.

doi:10.1155/2012/351832

Cited by 53 publications

(45 citation statements)

References 96 publications

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“…However, there is no functional analogue of plasmodesmata or gap junctions that would mediate crosstalk between neighbouring (Bloemendal & Kuck, 2013) hyphae in fruiting bodies. Intercellular communication in fungi relies on the diffusion of chemical signals through the extracellular space, such as pheromones, volatile compounds, and quorum-sensing molecules (Albuquerque & Casadevall, 2012;Cottier & Mühlschlegel, 2012;Wongsuk, Pumeesat, & Luplertlop, 2016;Kues et al, 2018), including small proteins (Wang et al, 2013;Gyawali et al, 2017). It has evolved to signal through a loosely occupied space or among unicells and primarily suits the needs of vegetative mycelium or yeast cells.…”

Section: (3) Cell-cell Communication and Signallingmentioning

confidence: 99%

Complex multicellularity in fungi: evolutionary convergence, single origin, or both?

2018

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Complex multicellularity represents the most advanced level of biological organization and it has evolved only a few times: in metazoans, green plants, brown and red algae and fungi. Compared to other lineages, the evolution of multicellularity in fungi follows different principles; both simple and complex multicellularity evolved via unique mechanisms not found in other lineages. Herein we review ecological, palaeontological, developmental and genomic aspects of complex multicellularity in fungi and discuss general principles of the evolution of complex multicellularity in light of its fungal manifestations. Fungi represent the only lineage in which complex multicellularity shows signatures of convergent evolution: it appears 8-11 times in distinct fungal lineages, which show a patchy phylogenetic distribution yet share some of the genetic mechanisms underlying complex multicellular development. To explain the patchy distribution of complex multicellularity across the fungal phylogeny we identify four key observations: the large number of apparently independent complex multicellular clades; the lack of documented phenotypic homology between these clades; the conservation of gene circuits regulating the onset of complex multicellular development; and the existence of clades in which the evolution of complex multicellularity is coupled with limited gene family diversification. We discuss how these patterns and known genetic aspects of fungal development can be reconciled with the genetic theory of convergent evolution to explain the pervasive occurrence of complex multicellularity across the fungal tree of life.

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Section: (3) Cell-cell Communication and Signallingmentioning

confidence: 99%

Complex multicellularity in fungi: evolutionary convergence, single origin, or both?

2018

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“…Notably, 3-octanone is a conidiation-inducing signal in the fungal genus Trichoderma (28), which includes several plant-symbiotic species (29). Trichoderma-produced 3-octanone have been shown to promote growth of plants such as A. thaliana and willow (30,31). In contrast, 1octen-3-ol induces defense responses in A. thaliana, suppresses growth and development of fungi and reduces growth, chlorophyll accumulation and seed germination in A. thaliana (32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

TheStreptomycesvolatile 3-octanone alters auxin/cytokinin and growth inArabidopsis thalianavia the gene familyKISS ME DEADLY

Dotson

Verschut

Flärdh

et al. 2020

Preprint

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“…Quorum sensing is also known from fungi [12,13] and best studied in Candida albicans [14]. The known quorum sensing molecules from fungi are structurally very different from those found in bacteria.…”

Section: Biofilm Infections Are a Therapeutic Challengementioning

confidence: 99%

Fungal Metabolites for the Control of Biofilm Infections

Estrela

Abraham

2016

Agriculture

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Many microbes attach to surfaces and produce a complex matrix of polymers surrounding their cells, forming a biofilm. In biofilms, microbes are much better protected against hostile environments, impairing the action of most antibiotics. A pressing demand exists for novel therapeutic strategies against biofilm infections, which are a grave health wise on mucosal surfaces and medical devices. From fungi, a large number of secondary metabolites with antimicrobial activity have been characterized. This review discusses natural compounds from fungi which are effective against fungal and bacterial biofilms. Some molecules are able to block the cell communication process essential for biofilm formation (known as quorum sensing), others can penetrate and kill cells within the structure. Several targets have been identified, ranging from the inhibition of quorum sensing receptors and virulence factors, to cell wall synthesizing enzymes. Only one group of these fungal metabolites has been optimized and made it to the market, but more preclinical studies are ongoing to expand the biofilm-fighting arsenal. The broad diversity of bioactive compounds from fungi, their activities against various pathogens, and the multi-target trait of some molecules are promising aspects of fungal secondary metabolites. Future screenings for biofilm-controlling compounds will contribute to several novel clinical applications.

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Communication in Fungi

Cited by 53 publications

References 96 publications

Complex multicellularity in fungi: evolutionary convergence, single origin, or both?

Complex multicellularity in fungi: evolutionary convergence, single origin, or both?

TheStreptomycesvolatile 3-octanone alters auxin/cytokinin and growth inArabidopsis thalianavia the gene familyKISS ME DEADLY

Fungal Metabolites for the Control of Biofilm Infections

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