Tourism routes are the configuration of resources and services into an experience. They are structured based on the characteristics of the local setting but also considering the tourists’ expectations motivations and interests. The objective of this manuscript is to present a methodological approach for the configuration and evaluation of tourism routes, using the municipality of Tenancingo, Mexico as a case study. The methodology followed consisted of three phases: 1) the identification and classification of resources; 2) the qualitative evaluation of the resources; and 3) the use of a route evaluation index to determine the suitability. The study concluded that the methodology allowed for the evaluation of different configurations, and the identification of the tourism route with the most potential, according to its characteristics.