Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?

Roche, Declan M.; Byers, Joseph; Smith, Debra; Glansdorp, Freija G.; Spring, David R.; Welch, Martin

doi:10.1099/mic.0.26977-0

Cited by 92 publications

(81 citation statements)

References 31 publications

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“…However, our findings also suggest that these enzymes have a previously unrecognized function: to abrogate the toxic effects of 1 and prevent the formation 4. This hypothesis is concurrent with recent discussions about a more complex role of lactonases in vivo (17). Second, this finding raises the enticing evolutionary prospect that 3-oxo-AHLs and their corresponding tetramic acids were selected for as a result of their fortuitous cytotoxic abilities and resistance to lactonase degradation, respectively.…”

Section: Resultssupporting

confidence: 62%

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Kaufmann

Sartorio

Lee

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

321

349

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Bacteria use small diffusible molecules to exchange information in a process called quorum sensing. An important class of autoinducers used by Gram-negative bacteria is the family of N-acylhomoserine lactones. Here, we report the discovery of a previously undescribed nonenzymatically formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its novel tetramic acid degradation product, 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione, are potent antibacterial agents. Bactericidal activity was observed against all tested Gram-positive bacterial strains, whereas no toxicity was seen against Gram-negative bacteria. We propose that Pseudomonas aeruginosa utilizes this tetramic acid as an interference strategy to preclude encroachment by competing bacteria. Additionally, we have discovered that this tetramic acid binds iron with comparable affinity to known bacterial siderophores, possibly providing an unrecognized mechanism for iron solubilization. These findings merit new attention such that other previously identified autoinducers be reevaluated for additional biological functions.tetramic acid ͉ bactericidal agents ͉ evolution

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Section: Resultssupporting

confidence: 62%

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Kaufmann

Sartorio

Lee

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

321

349

View full text Add to dashboard Cite

show abstract

“…Quorum sensing also plays a significant role in regulation of gene expression as well as the cell density dependent signaling mechanism. When the required cell density is achieved, the autoinducers are secreted which bind to the transcriptional factors and cause the activation or the suppression of certain genes that could be beneficial to the pathogen [107]. The autoinducers known to trigger the quorum sensing mechanism significantly vary among Gram negative and positive bacteria.…”

Section: Biofilms and Quorum Sensingmentioning

confidence: 99%

Biofilms: Microbial Cities of Scientific Significance

Ramachandran¹

2014

JMEN

113

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“…The fatty amides are also N -fatty acylated amines and unsubstituted amides, and many simple amides have interesting biological activities in various organisms. Fatty acyl homoserine lactones are fatty amides involved in bacterial quorum sensing (16).…”

Section: Fatty Acyls [Fa]mentioning

confidence: 99%

A comprehensive classification system for lipids

Fahy

Subramaniam

Brown

et al. 2005

Journal of Lipid Research

1,467

685

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Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, "lipidomics," in the context of genomics and proteomics is crucial to understanding cellular physiology and pathology; consequently, lipid biology has become a major research target of the postgenomic revolution and systems biology. To facilitate international communication about lipids, a comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by our lipid community. As an initial step in this development, we divide lipids into eight categories (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, prenol lipids, saccharolipids, and polyketides) containing distinct classes and subclasses of molecules, The goal of collecting data on lipids using a "systems biology" approach to lipidomics requires the development of a comprehensive classification, nomenclature, and chemical representation system to accommodate the myriad lipids that exist in nature. Lipids have been loosely defined as biological substances that are generally hydrophobic in nature and in many cases soluble in organic solvents (1). These chemical properties cover a broad range of mole-

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Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?

Cited by 92 publications

References 31 publications

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Biofilms: Microbial Cities of Scientific Significance

A comprehensive classification system for lipids

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