Communicative misalignment in Autism Spectrum Disorder

Wadge, Harshali; Brewer, Rebecca; Bird, Geoffrey; Toni, Ivan; Stolk, Arjen

doi:10.1016/j.cortex.2019.01.003

Cited by 22 publications

(7 citation statements)

References 67 publications

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“…One of the core features of autism and other neurodevelopmental disorders such as fragile X and Angelman’s syndromes is the inability of the individual to interact socially with other individuals [43–45], which is a diagnostic criterion in autism. It is also a common feature in studies using mouse models for autism [46].…”

Section: Discussionmentioning

confidence: 99%

Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring

Chauhan

2019

Behav Brain Funct

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Traumatic injury (TI) during pregnancy increases the risk for developing neurological disorders in the infants. These disorders are a major concern for the well-being of children born after TI during pregnancy. TI during pregnancy may result in preterm labor and delivery, abruptio placentae, and/or fetomaternal hemorrhage. Drosophila melanogaster (fruit fly) is a widely used model to study brain and behavioral disorders in humans. In this study, we analyzed the effects of TI to female fruit flies on the development timing of larvae, social interaction and the behavior of offspring flies. TI to the female flies was found to affect the development of larvae and the behavior of offspring flies. There was a significant increase in the length of larvae delivered by traumatically injured maternal flies as compared to larvae from control maternal flies (without TI). The pupae formation from larvae, and the metamorphosis of pupae to the first generation of flies were faster in the TI group than the control group. Negative geotaxis and distance of the fly to its nearest neighbor are parameters of behavioral assessment in fruit flies. Negative geotaxis significantly decreased in the first generation of both male (p = 0.0021) and female (p = 0.0426) flies. The distance between the first generation of flies to its nearest neighbor was shorter in both male and female offspring flies in the TI group as compared to control group flies. These results indicate that TI to the female flies affected the development of larvae and resulted in early delivery, impaired social interaction and behavioral alterations in the offspring.

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Section: Discussionmentioning

confidence: 99%

Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring

Chauhan

2019

Behav Brain Funct

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“…This framework is supported by empirical evidence, including neural observations that reveal communicators and addressees using the same computational procedures, implemented in the same neuronal substrates, and operating over temporal scales separate from behavioral dynamics (Stolk et al, 2013; Stolk, Noordzij, Verhagen, et al, 2014). Research has also shown that individuals with autism spectrum disorder may have difficulty meeting the alignment demands of interaction, leading to more individual exploration when constructing interactive behaviors (Wadge et al, 2019).…”

Section: The Outlook: New Reasons For Optimismmentioning

confidence: 99%

The Emerging Science of Interacting Minds

Wheatley,

Thornton,

Stolk

et al. 2023

Perspect Psychol Sci

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For over a century, psychology has focused on uncovering mental processes of a single individual. However, humans rarely navigate the world in isolation. The most important determinants of successful development, mental health, and our individual traits and preferences arise from interacting with other individuals. Social interaction underpins who we are, how we think, and how we behave. Here we discuss the key methodological challenges that have limited progress in establishing a robust science of how minds interact and the new tools that are beginning to overcome these challenges. A deep understanding of the human mind requires studying the context within which it originates and exists: social interaction.

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“…For example, when adults with ASC switch partners during a referential task, they are slower to adapt and relatively less likely than NT peers to incorporate new information produced by conversation partners (Nadig et al, 2015). Similarly, during spatial configuration tasks, autistic adults are less likely than NT peers to demonstrate interpersonal agreement on the meaning of their communicative behaviors, particularly when interacting with a new partner (Wadge et al, 2019). Given the importance of spontaneous, dyadic communication in everyday life, it is critical to examine conversational skills in less structured, naturalistic contexts.…”

Section: Conversational Adaptation In Ascmentioning

confidence: 99%

Conversational adaptation in children and teens with autism: Differences in talkativeness across contexts

et al. 2022

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Successful social communication is complex; it relies on effectively deploying and continuously revising one's behavior to fit the needs of a given conversation, partner, and context. For example, a skilled conversationalist may instinctively become less talkative with a quiet partner and more talkative with a chattier one. Prior research suggests that behavioral flexibility across social contexts can be a particular challenge for individuals with autism spectrum condition (ASC), and that difficulty adapting to the changing needs of a conversation contributes to communicative breakdowns and poor social outcomes. In this study, we examine whether reduced conversational adaptation, as measured by talkativeness, differentiates 48 verbally fluent children and teens with ASC from 50 neurotypical (NT) peers matched on age, intelligence quotient, and sex ratio. Participants completed the Contextual Assessment of Social Skills with two novel conversation partners. The first acted interested in the conversation and talked more (Interested condition), while the second acted bored and talked less (Bored condition). Results revealed that NT participants emulated their conversation partner's behavior by being more talkative in the Interested condition as compared to the Bored condition (z = 9.92, p < 0.001). In contrast, the ASC group did not differentially adapt their behavior to the Bored versus Interested context, instead remaining consistently talkative in both (p = 0.88). The results of this study have implications for understanding social communication and behavioral adaptation in ASC, and may be valuable for clinicians interested in improving conversational competence in verbally fluent individuals with autism. Lay Summary Social communication—including everyday conversations—can be challenging for individuals on the autism spectrum. In successful conversations, people tend to adjust aspects of their language to be more similar to their partners'. In this study, we found that children and teens with autism did not change their own talkativeness in response to a social partner who was more or less talkative, whereas neurotypical peers did. These findings have clinical implications for improving conversational competence in verbally fluent individuals with autism.

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Communicative misalignment in Autism Spectrum Disorder

Cited by 22 publications

References 67 publications

Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring

Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring

The Emerging Science of Interacting Minds

Conversational adaptation in children and teens with autism: Differences in talkativeness across contexts

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