Community Acquired Bacteremia by Sphingomonas paucimobilis : Two Rare Case Reports.

Abstract

S.paucimobilis has a diverse nutritional substrate spectrum and found in both environmental and hospital settings. Sphingomonas paucimobilis is rarely isolated from clinical specimen. This low virulence organism since has been reported to cause a variety of diseases since 1979. It has been reported to be associated with both community acquired and nosocomial diseases including bacteremia, catheter related sepsis, diarrhoeal diseases, peritonitis, meningitis, cutaneous infections, endopthalmitis, visceral infections , urinary tract infections etc. We report two cases of community acquired primary bacteremia by Sphingomonas paucimobilis. One of the patients was 55-year-old female who had gallbladder carcinoma and the other was a 2-year-old healthy male who had no history of any underlying disease. Both got admission in hospital with complaints of pyrexia. Blood culture yielded S.paucimobilis which was found to be sensitive to quinolones, chloramphenicol, carbapenems, aminoglycosides and beta lactams except penicillin and amoxicillin.

Comprehensive detection and identification of bacterial DNA in the blood of patients with sepsis and healthy volunteers using next-generation sequencing method - the observation of DNAemia

“…Within these, one could see mainly bacteria that often exist in the hospital environment, like Pseudomonadales , Enterobacteriales , Bacillales orders and which are typically known to cause sepsis [20, 21]. Less common were bacteria belonging to the Sphingomonadales order and Cellulosimicrobium genus (within Actinomycetales order), however, in the literature investigators described cases of bacteraemia caused also by these taxa [22–24]. The most surprising was the fact that in the blood of patients with sepsis we detected DNA of Rhizobiales order which fix nitrogen and are symbiotic with plant roots.…”

Activation and Function of iNKT and MAIT Cells

“…They are abundant microbes in the environment (Kampfer, Witzenberger, Denner, Busse, & Neef, 2002) and can be detected in some human fecal samples (Selmi et al, 2003), but they are not an abundant organism in the intestine and they are not highly pathogenic (Nandy, Dudeja, Das, & Tiwari, 2013). Exposure to Sphingomonadaceae bacteria has been shown to stimulate iNKT cells in vitro and in vivo (Kinjo et al, 2005;Mattner et al, 2005;Sriram, Du, Gervay-Hague, & Brutkiewicz, 2005).…”

Sphingomonas paucimobilis from Blood Stream Infection to Spondylodiscitis

“…He didn't suffer from any diseases before admission on hospital. Belong to the antibiotic therapy, the organism has been reported to be resistant to penicillin and first-generation cephalosporin's because of the production of chromosomally encoded beta-lactamase production and susceptible to tetracycline, chloramphenicol, aminoglycosides, carbapenems, fluroquinolone and trimethoprim/sulphamethaxazole [6,17,18]. Aminoglycoside plus a third-generation cephalosporin have been recommended as suitable antibiotics for treatment of S. paucimobilis infections in previous study [6].…”