Community-acquired invasive liver abscess syndrome caused by a K1 serotype Klebsiella pneumoniae isolate in Brazil: a case report of hypervirulent ST23

Coutinho, Rosane Luiza; Visconde, Marina Francisco; Descio, Fernanda J; Nicoletti, Adriana G.; Pinto, Flavia Cl; Silva, Ana Carolina R da; Rodrigues-Costa, Fernanda; Gales, Ana Cristina; Furtado, Guilherme Hc

doi:10.1590/0074-0276140196

Cited by 39 publications

(32 citation statements)

References 8 publications

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“…An underlying hepatobiliary disease was not found. His travel history was positive for Brazil, where cases of infections due to K1 serotype K. pneumoniae have been described [17]. In Europe several cases have also been described, with many cases in France [18], [19].…”

Section: Discussionmentioning

confidence: 99%

First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016

Pichler

Büchsel

Rossen

et al. 2017

New Microbes and New Infections

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We report a case of severe infection with liver abscess and endophthalmitis caused by a hypervirulent Klebsiella pneumoniae strain in an immunocompetent German male patient without travel history to Asia. Phenotypic and molecular characterization showed high similarity to the reference genome NTUH-K2044 isolated in Asia. The isolate was assigned as ST2398 (clonal complex 66). The findings underline global spread of hypervirulent Klebsiella pneumoniae strains to Europe.

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Section: Discussionmentioning

confidence: 99%

First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016

Pichler

Büchsel

Rossen

et al. 2017

New Microbes and New Infections

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show abstract

“…Virulence genes including rmpA and magA were detected by PCR. The primers used to perform PCR were designed as described by Ref …”

Section: Methodsmentioning

confidence: 99%

“…In the last two decades, a new hypervirulent strain of K. pneumoniae (hvKP) has increasingly reported in Southeastern Asia and other non‐Asian countries, including Brazil . The invasive strain of hvKP has caused a fatal syndrome in humans including pulmonary embolism, abscesses, meningitis, endophthalmitis, osteomyelitis, or brain abscess and pyogenic liver abscess .…”

Section: Introductionmentioning

confidence: 99%

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Anzai

Júnior

Peruchi

et al. 2017

J of Medical Primatology

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“…A new hypermucoviscous clinical variant of K. pneumoniae (hvKP) found in community-acquired pyogenic liver abscesses (CA-PLA) and septic endophthalmitis was reported in Taiwan in 1986 [1]. Life-threatening liver abscesses, pneumonia, meningitis, bloodstream infections (BSI) or endophthalmitis caused by hvKP have been increasingly reported in the USA, Brazil, Germany, Japan, and Australia [2][3][4][5][6]. These infections are often community-acquired [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

Xiao

Yao

Zhou

et al. 2017

J Infect Dev Ctries

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Introduction: Reports of hypermucoviscous Klebsiella pneumoniae (hvKP) isolated from fluids other than blood or abscess are rare. The aim of the study was to compare clinical and microbiological characteristics of hvKP found in blood or abscess fluid with those isolated from other loci. Methodology: A total of 24 non-repetitive hvKP isolates were collected from January 2013 to June 2014 from patients with hvKP infections. There were 15 in Group 1 (fluid other than blood or abscess) and 9 in Group 2 (blood or abscess fluid). Medical records of all patients were reviewed. Capsular polysaccharide (CPS) typing, virulence factor determination, and multilocus sequence typing (MLST) of hvKP isolates were performed. Results: Seventeen sequence types (STs) and 6 capsular serotypes were identified. Type K2 CC65 was most commonly identified in Group 1 and type K2 CC86 in Group 2. Deletion of pLVPK-derived loci were found in K2 and non-K1/K2 hvKP strains. Two virulent genes, fimH and ycfM, were identified more frequently in Group 2 than in Group 1. There was no difference in the frequency of other virulent genes or serotypes in the two groups. Two imipenem resistant hvKP isolates (cr-hvKP) were found in non-blood or abscess samples. Conclusions: hvKP isolated from different body fluids had similar clinical and microbiological characteristics. cr-hvKP identified in non-blood or abscess samples should raise our attention to the challenging situation and management of hvKP infection.

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Community-acquired invasive liver abscess syndrome caused by a K1 serotype Klebsiella pneumoniae isolate in Brazil: a case report of hypervirulent ST23

Cited by 39 publications

References 8 publications

First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016

First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016

First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Microbiological characteristics of hypermucoviscous Klebsiella pneumoniae isolates from different body fluids

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