Community-acquired PVL+ MRSA in Ireland: a preliminary report

Rossney, Angela S.; Morgan, P. M.; O’Connell, Brian

doi:10.2807/esw.10.16.02684-en

Cited by 8 publications

(7 citation statements)

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“…The results of this study show that 76% of pvl-positive MRSA isolates recovered in Ireland as part of the present investigation were CA, confirming an earlier preliminary observation that CA-MRSA is an emerging problem in Ireland (36). However, although the overall proportion of MRSA isolates carrying pvl was 1.8% among the 1,389 isolates investigated, during the prospective study where 7.5% (30/401) of isolates were CA-MRSA strains, only 6.7% of isolates (2/30) from patients with an epidemiological history of CA-MRSA carried pvl genes and the carriage of pvl was not restricted to CA-MRSA.…”

Section: Discussionsupporting

confidence: 77%

“…MRSA has been a widespread problem in Irish hospitals, where strains have been well characterized (35,40,45) for many years, but there are very few published data regarding CA-MRSA in Ireland (36). In order to increase our understanding of CA-MRSA so that effective infection control measures for combating the spread of CA-MRSA in both the community and the hospital can be established, it is vital that the clinical, epidemiological, and biological characteristics of CA-MRSA are determined.…”

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confidence: 99%

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The Emergence and Importation of Diverse Genotypes of Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring the Panton-Valentine Leukocidin Gene ( pvl ) Reveal that pvl Is a Poor Marker for Community-Acquired MRSA Strains in Ireland

et al. 2007

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) carrying pvl is an emerging problem worldwide. CA-MRSA tends to harbor staphylococcal cassette chromosome mec type IV (SCC mec IV), to be non-multiantibiotic resistant, and to have different genotypes from the local hospital-acquired MRSA (HA-MRSA). However, in Ireland, 80% of HA-MRSA isolates have the non-multiantibiotic-resistant genotype ST22-MRSA-IV. This study investigated MRSA isolates from Ireland (CA-MRSA, health care-associated MRSA, and HA-MRSA) for the carriage of pvl and determined the genotypic characteristics of all pvl -positive isolates identified. All 1,389 MRSA isolates were investigated by antibiogram-resistogram typing and SmaI DNA macrorestriction analysis. pvl -positive isolates were further characterized by multilocus sequence typing and SCC mec , agr , and toxin gene typing. Twenty-five (1.8%) MRSA isolates belonging to six genotypes (ST30, ST8, ST22, ST80, ST5, and ST154) harbored pvl . Nineteen of these (76%) were CA-MRSA isolates, but a prospective study of MRSA isolates from 401 patients showed that only 6.7% (2/30) of patients with CA-MRSA yielded pvl -positive isolates. Thus, pvl cannot be used as a sole marker for CA-MRSA. Fifty-two percent of pvl -positive MRSA isolates were recovered from patients with skin and soft tissue infections; thirty-six percent were from patients of non-Irish ethnic origin, reflecting the increasing heterogeneity of the Irish population due to immigration. All 25 pvl -positive isolates carried SCC mec IV; 14 (56%) harbored SCC mec IV.1 or IV.3, and the remaining 11 isolates could not be subtyped. This study demonstrates that pvl is not a reliable marker for CA-MRSA in Ireland and reveals the emergence and importation of diverse genotypes of pvl -positive MRSA in Ireland.

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Section: Discussionsupporting

confidence: 77%

mentioning

confidence: 99%

The Emergence and Importation of Diverse Genotypes of Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring the Panton-Valentine Leukocidin Gene ( pvl ) Reveal that pvl Is a Poor Marker for Community-Acquired MRSA Strains in Ireland

et al. 2007

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“…The MRSA isolate from this patient was resistant to flucloxacillin and fucidic acid but sensitive to ciprofloxacin and erythromycin. This unusual sensitivity pattern is similar to those of previously published Irish non-ophthalmic CAMRSA 1. The atypical sensitivities and the history suggested a CAMRSA infection, so specimens were sent to the National MRSA Reference Laboratory for further testing.…”

Section: Commentsupporting

confidence: 83%

Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA)

Charalampidou

Connell

Fennell

et al. 2007

British Journal of Ophthalmology

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“…These strains mainly affect young and healthy individuals who have not had contact with healthcare, suggesting that infection is acquired in the community [4,5]. Cases of PVL containing S. aureus (PVL‐SA) pneumonia have been reported across Europe [2,6,7] but the prevalence of PVL strains amongst isolates submitted to national reference units is variable [1,8–11].…”

Section: Introductionmentioning

confidence: 99%

Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England

Shallcross

Williams

Hopkins

et al. 2010

Clinical Microbiology and Infection

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Recently, there has been international concern at the rapid emergence of highly pathogenic strains of Staphylococcus aureus associated with a toxin called Panton-Valentine leukocidin (PVL). In the UK, these strains are considered to be rare and mainly severe. We estimate the proportion of staphylococcal infections that are caused by strains containing the PVL genes, and describe risk factors for these infections. Three hundred and ninety consecutive S. aureus clinical isolates, submitted for routine diagnostic purposes were screened for PVL genes. Risk factors for infection were identified from the patient medical record. 9.7% (95% CI 7.0-13.1%) of clinical isolates and 20.8% of skin and soft tissue specimens contained the genes for PVL. Methicillin-resistant S. aureus with PVL was rare (0.8% of all isolates) but PVL with methicillin-sensitive S. aureus was common (9.0% of all specimens). PVL infection was more frequent in males (OR 3.0, 95% CI 1.3-7.0), and in young adults aged 20-39 years (OR 3.7, 95% CI 1.3-10.4). Over half of PVL positive S. aureus infections originated in patients based in the community. Community-onset PVL-associated disease is common in the UK and mainly causes skin and soft tissue infections that do not require admission to hospital. Consideration should be given to current infection control strategy, which advocates household contact screening and decolonization on the assumption that PVL-associated disease is rare.

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Community-acquired PVL+ MRSA in Ireland: a preliminary report

Abstract: Cases of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection were recently detected for the first time in Ireland

Cited by 8 publications

References 0 publications

The Emergence and Importation of Diverse Genotypes of Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring the Panton-Valentine Leukocidin Gene ( pvl ) Reveal that pvl Is a Poor Marker for Community-Acquired MRSA Strains in Ireland

The Emergence and Importation of Diverse Genotypes of Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring the Panton-Valentine Leukocidin Gene ( pvl ) Reveal that pvl Is a Poor Marker for Community-Acquired MRSA Strains in Ireland

Preseptal cellulitis caused by community acquired methicillin resistant Staphylococcus aureus (CAMRSA)

Panton-Valentine leukocidin associated staphylococcal disease: a cross-sectional study at a London hospital, England

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