Community-acquired urinary tract infection: age and gender-dependent etiology

Lo, Denise Swei; Shieh, Huei Hsin; Ragazzi, Selma Lopes Betta; Koch, Vera H.; Martinez, Marina Baquerizo; Gilio, Alfredo Elias

doi:10.5935/0101-2800.20130016

Cited by 44 publications

(43 citation statements)

References 24 publications

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“…16 In the same study frequency of cancer of the prostate was 7% while in current study it was 5% which is quite similar. Of all the four cancer patients, urine culture was positive and serum PSA level was insignificant.…”

supporting

confidence: 64%

Post Transurethral Resection of Prostate Histopathological Proven Chronic Prostatitis

2016

J Surg Pak

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supporting

confidence: 64%

Post Transurethral Resection of Prostate Histopathological Proven Chronic Prostatitis

2016

J Surg Pak

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“…Future surveillance studies will make this a priority. Furthermore, age and gender-dependent etiology was not analysed, which has shown to be important in determining optimal empiric therapy [36]. Data regarding the use of specific antimicrobials prior to hospitalisation was incomplete and, therefore, could not be used to identify correlations between the consumption of specific antimicrobials and the presence of MDR strains as has been established as significant by other studies [37].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance in patients with urinary tract infections and the impact on empiric therapy in Serbia

Zec

Despotović²,

Spurnic-Radovanovic³

et al. 2016

J Infect Dev Ctries

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Introduction: Surveillance of antimicrobial resistance is essential in establishing treatment guidelines for urinary tract infections. The aim of this pilot study was to analyse resistance rates of pathogens, across different demographics and determine whether adjustments in empiric therapy should be considered for different age and gender groups. Methodology: A 5-year retrospective study included 256 patients hospitalised, under the initial diagnosis of Fever of Unknown Origin who were then subsequently diagnosed with a urinary tract infection at the Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia. Patients were evaluated using demographic, clinical, and antimicrobial resistance data with appropriate statistical analysis including ANOVA significance testing, univariate, and multivariate analysis. Results: Resistance rates were above the threshold of 20% for the majority of the antimicrobials tested, the only exception being carbapenems. Amikacin, cefepime, and norfloxacin were agents that could be effectively used as empiric therapy in younger adults with resistance rates of 4.2, 8.0, and 10.0%, respectively. Moderate resistance rates of 17.4% for amikacin and 19.1% for cefepime were observed in the age group 35-64 years. High resistance rates were observed for all antimicrobials among patients 65 years and over. Among male patients, resistance rates to most antimicrobials were high. In female patients, amikacin and cefepime had resistance rates less than 20%. Younger age presented as a negative risk factor for infection by a multi-drug resistant pathogen. Conclusion: Age and gender demonstrated to be significant factors for determining proper empiric therapy; large-scale studies from Serbia are needed to solidify these findings.

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“…For similar reasons, patients with diabetes are at risk of recurrent UTIs that, over time, pose more risk of resistance [3,12]. While males are at lower risk of UTIs than females, males are at higher risk of a UTI with an MDR pathogen [3,13,14].…”

Section: Risk Factors For Utis Caused By Mdr Uropathogensmentioning

confidence: 99%

Clinical Management of an Increasing Threat: Outpatient Urinary Tract Infections Due to Multidrug-Resistant Uropathogens: Table 1.

et al. 2016

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Urinary tract infections (UTIs) are among the most commonly treated bacterial infections. Over the past decade, antimicrobial resistance has become an increasingly common factor in the management of outpatient UTIs. As treatment options for multidrugresistant (MDR) uropathogens are limited, clinicians need to be aware of specific clinical and epidemiological risk factors for these infections. Based on available literature, the activity of fosfomycin and nitrofurantoin remain high for most cases of MDR Escherichia coli UTIs. Trimethoprim-sulfamethoxazole retains clinical efficacy, but resistance rates are increasing internationally. Beta-lactam agents have the highest rates of resistance and lowest rates of clinical success. Fluoroquinolones have high resistance rates among MDR uropathogens and are being strongly discouraged as first-line agents for UTIs. In addition to accounting for local resistance rates, consideration of patient risk factors for resistance and pharmacological principles will help guide optimal empiric treatment of outpatient UTIs.

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Community-acquired urinary tract infection: age and gender-dependent etiology

Cited by 44 publications

References 24 publications

Post Transurethral Resection of Prostate Histopathological Proven Chronic Prostatitis

Post Transurethral Resection of Prostate Histopathological Proven Chronic Prostatitis

Antimicrobial resistance in patients with urinary tract infections and the impact on empiric therapy in Serbia

Clinical Management of an Increasing Threat: Outpatient Urinary Tract Infections Due to Multidrug-Resistant Uropathogens: Table 1.

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