Between March 23, 2021, and December 31, 2022, the Mobile Vaccine Program (MVP) vaccinated 5044 individuals from medically‐underserved communities in Middle Tennessee identified through and guided by a collaboration of local community agencies. The primary objective of the MVP was to vaccinate individuals for COVID‐19 who had barriers to traditional mass vaccine strategies through community‐guided strategies and partnerships. Three strategies were developed and implemented with community partners and their affiliated community health workers (CHWs). The strategies included pop‐up vaccination clinics at community partner events, CHW‐guided door‐to‐door in‐home vaccination, and community partner‐initiated homebound referrals for vaccination.