1997
DOI: 10.1111/j.1528-1157.1997.tb01136.x
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Community‐Based Study of Lennox‐Gastaut Syndrome

Abstract: Summary: Purpose: Before 1986, the spectrum of childhood epilepsies, including Lennox-Gastaut syndrome (LGS) and Doose syndrome (DS), known collectively as "epilepsia myoclonica astatica," was believed to represent a single disease. More recently, some investigators have considered these syndromes to be parts of a continuum. To clarify these theories, neurobiologic factors of the syndromes were studied to determine which qualities were shared and which were unique.Methods: A retrospective (1975)(1976)(1977)(19… Show more

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Cited by 81 publications
(78 citation statements)
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“…The patient is a 5-y-old boy with epileptic encephalopathy (EE) presenting as frequent mixed seizure types, characteristic EEG abnormalities, and developmental regression, collectively known as Lennox-Gastaut syndrome (LGS) (31). Birth was complicated by twin gestation and delivery at 35 wk gestational age.…”
Section: Case Reportmentioning
confidence: 99%
“…The patient is a 5-y-old boy with epileptic encephalopathy (EE) presenting as frequent mixed seizure types, characteristic EEG abnormalities, and developmental regression, collectively known as Lennox-Gastaut syndrome (LGS) (31). Birth was complicated by twin gestation and delivery at 35 wk gestational age.…”
Section: Case Reportmentioning
confidence: 99%
“…In 23-54% of these children, IS evolves to LGS (4)(5)(6). Conversely, 20-36% of the children with LGS have a history of IS (6)(7)(8)(9). The occurrence of LGS has been found to be 0.24 per 1,000 live births or two in 100,000 children aged 0-14 years (9).…”
mentioning
confidence: 99%
“…Conversely, 20-36% of the children with LGS have a history of IS (6)(7)(8)(9). The occurrence of LGS has been found to be 0.24 per 1,000 live births or two in 100,000 children aged 0-14 years (9). In the study of Ohtahara et al (6), IS evolved to LGS in 54% of the children, and 36% of the children with LGS had a history of IS.…”
mentioning
confidence: 99%
“…However, as shown in a communitybased study, prenatal or perinatal abnormalities are not necessarily in correlation with the severity of epilepsy [40]. At follow-up of at least 10 years, 5-13% of individuals were in remission and 8% were not mentally retarded.…”
Section: Catastrophic Epilepsies Of Childhoodmentioning
confidence: 87%