Community-driven research in the canadian arctic: dietary exposure to methylmercury and gastric health outcomes

Walker, Emily; Girgis, Safwat; Yuan, Yan; Goodman, Karen J.

doi:10.1080/22423982.2021.1889879

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…For example, fish and whale contaminated with methylmercury have been shown to increase the risk of gastric cancer in Arctic communities. In a study by Walker et al (2021), analysis of 80 gastric biopsies found evidence of intestinal metaplasia, atrophy, and severe chronic gastritis in 17%, 29%, and 38% of cases, respectively [124]. Interestingly, selenium intake appeared to counter the harmful effects of methylmercury contamination.…”

Section: Routes Of Infectionmentioning

confidence: 99%

Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?

Finlayson-Trick

Barker

Manji

et al. 2021

Gastrointestinal Disorders

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The Canadian Arctic has a long history with diarrheal disease, including outbreaks of campylobacteriosis, giardiasis, and salmonellosis. Due to climate change, the Canadian Arctic is experiencing rapid environmental transformation, which not only threatens the livelihood of local Indigenous Peoples, but also supports the spread, frequency, and intensity of enteric pathogen outbreaks. Advances in diagnostic testing and detection have brought to attention the current burden of disease due to Cryptosporidium, Campylobacter, and Helicobacter pylori. As climate change is known to influence pathogen transmission (e.g., food and water), Arctic communities need support in developing prevention and surveillance strategies that are culturally appropriate. This review aims to provide an overview of how climate change is currently and is expected to impact enteric pathogens in the Canadian Arctic.

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Section: Routes Of Infectionmentioning

confidence: 99%

Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?

Finlayson-Trick

Barker

Manji

et al. 2021

Gastrointestinal Disorders

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“…Analysis from the NutriNet-Santé cohort showed that higher Se intake was associated with a decreased digestive cancer risk [ 11 ]. In addition, Se was also reported to have a role in reducing the effects of known carcinogens [ 12 ]. With continued advances, there also is evidence that Se could have a role in gastric cancer therapy [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case–control study

Zyambo¹,

Kelly²,

Kayamba³

2022

ecancer

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There is some evidence that Selenium (Se) is protective against gastric carcinogenesis, but these data are inconsistent. With a predicted increase in gastric cancer cases in Africa over the next 20 years, there is an urgent need to identify strategies that could be employed to prevent the surge. The objective of our study was to investigate the association between gastric cancer and plasma Se levels in Zambian adults. Our method used a case-control study with cases having either confirmed gastric cancer or premalignancies and controls having none. In addition, we measured antibodies against Helicobacter pylori and human immunodeficiency virus. Data were analysed with Stata 15 software using standard statistical methods. Using a normal reference range for Se of 0.9-1.9 µmol/L, 140/159 (88%) study participants had Se deficiency. Plasma Se levels were similar in all the three groups; 0.33 (interquartile range (IQR) 0.14-0.64) µmol/L for patients with gastric cancer, 0.38 (IQR 0.21-0.60) µmol/L for premalignant lesions and 0.28 (IQR 0.14-0.64) µmol/L in controls, (p-values = 0.35 and 0.34, respectively). In conclusion, we found no association between plasma Se levels and gastric cancer or premalignant lesions among adult Zambian adults.

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The relationship of 50 bp deletion in the promoter region of SOD1 gene with viscosity and trace elements in chronic gastritis with Helicobacter Pylori: A case study

Ergün

Doğaner

Koç

et al. 2022

Journal of Trace Elements in Medicine and Biology

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Community-driven research in the canadian arctic: dietary exposure to methylmercury and gastric health outcomes

Cited by 5 publications

References 53 publications

Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?

Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?

Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case–control study

The relationship of 50 bp deletion in the promoter region of SOD1 gene with viscosity and trace elements in chronic gastritis with Helicobacter Pylori: A case study

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