Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda

Lee, Yang Jae; Ssekalo, Ibrahim; Kazungu, Rauben; Blackwell, Timothy S.; Muwereza, Peter; Wu, Yuefeng; Sáenz, José B.

doi:10.1016/j.heliyon.2022.e12612

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…It should be noted, however, that in areas with low clarithromycin resistance, this therapy is still prescribed as the first-line treatment. Standard triple therapy, consisting of clarithromycin, amoxicillin, and omeprazole for 14 consecutive days, can effectively eradicate H. pylori in rural areas of eastern Uganda ( Lee et al., 2022 ). Studies documented that despite the unsatisfactory efficacy of standard triple therapy, vonoprazan triple therapy (vonoprazan, amoxicillin, and clarithromycin) achieves high eradication rates of over 90% and esomeprazole triple therapy (levofloxacin, esomeprazole, and clarithromycin) has the highest eradication rate in western countries ( Rokkas et al., 2021 ).…”

Section: Treatmentmentioning

confidence: 99%

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Sun,

Yuan,

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

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Helicobacter pylori, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above, H. pylori has different pathogenic mechanisms, including colonization and virulence factor expression. It is essential to make accurate diagnoses and provide patients with effective treatment to achieve positive clinical outcomes. Detection of H. pylori can be accomplished invasively and noninvasively, with both having advantages and limitations. To enhance therapeutic outcomes, novel therapeutic regimens, as well as adjunctive therapies with probiotics and traditional Chinese medicine, have been attempted along with traditional empiric treatments, such as triple and bismuth quadruple therapies. An H. pylori infection, however, is difficult to eradicate during treatment owing to bacterial resistance, and there is no commonly available preventive vaccine. The purpose of this review is to provide an overview of our understanding of H. pylori infections and to highlight current treatment and diagnostic options.

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Section: Treatmentmentioning

confidence: 99%

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Sun,

Yuan,

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

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Helicobacter pylori infection and associated risk factors among HIV-positive and HIV-negative individuals in Northern Ethiopia

Abadi,

Teklu,

Wondmagegn

et al. 2024

Journal of Infection and Chemotherapy

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Prevalence and associated risk factors of Helicobacter pylori infection in community households in Lanzhou city

Zhou,

Zheng,

Wang

et al. 2024

World J Gastroenterol

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BACKGROUND Helicobacter pylori (H. pylori ) infection exhibits a familial clustering phenomenon. AIM To investigate the prevalence of H. pylori infection, identify associated factors, and analyze patterns of transmission within families residing in the community. METHODS From July 2021 to September 2021, a total of 191 families (519 people) in two randomly chosen community health service centers in the Chengguan District of Lanzhou in Gansu Province, were recruited to fill out questionnaires and tested for H. pylori infection. Individuals were followed up again from April 2023 and June 2023 to test for H. pylori infection. The relationship between variables and H. pylori infection was analyzed using logistic regression and generalized linear mixed models. RESULTS In 2021, the individual-based H. pylori infection rate was found to be 47.0% (244/519), which decreased to 38.1% (177/464) in 2023. Additionally, the rate of individual-based H. pylori new infection was 22.8% (55/241). The family-based H. pylori infection rate in 2021 was 76.9% (147/191), which decreased to 67.1% (116/173) in 2023, and the rate of family-based H. pylori new infection was 38.6% (17/44). Individual H. pylori infection was positively correlated with age, body mass index (BMI), eating food that was excessively hot, frequent acid reflux, bloating, and halitosis symptoms, and negatively correlated with family size and nut consumption. New individual H. pylori infection was positively correlated with BMI, other types of family structures, drinking purified water, and frequent heartburn symptoms, while negatively correlated with the use of refrigerators and following a regular eating schedule. A larger living area was an independent protective factor for H. pylori infection in households. Frequently consuming excessively hot food and symptoms of halitosis were independent risk factors for H. pylori infection in individuals; frequent consumption of nuts was an independent protective factor for H. pylori infection. Other types of family structure, drinking purified water, and frequent heartburn symptoms were independent risk factors for new individual H. pylori infection; the use of a refrigerator was an independent protective factor for new H. pylori infections. CONCLUSION The household H. pylori infection rate in Lanzhou is relatively high and linked to socio-demographic factors and lifestyles. Eradication efforts and control of related risk factors are recommended in the general population.

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Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda

Cited by 3 publications

References 52 publications

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Helicobacter pylori infection and associated risk factors among HIV-positive and HIV-negative individuals in Northern Ethiopia

Prevalence and associated risk factors of Helicobacter pylori infection in community households in Lanzhou city

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