Community Urinary Tract Infection due to ESBL producing E. coli: epidemiology and susceptibility to oral antimicrobials including Mecillinam

Abstract

Background: There is increasing incidence of (Extended spectrumbeta lactamases) ESBL producing E. coli causing community urinary tract infections (UTI). The primary objective of this study was to study the epidemiological factors associated with ESBL positive community acquired uropathogenic E. coli isolates and to determine their susceptibility to newer oral drugs including mecillinam. Methods: In this prospective study, from total of 140 community isolates of E. coli causing UTI, ESBL was detected by Clinical Laboratory Standards Institute criteria. Drug susceptibility was done by Kirby-Bauer method disc diffusion method for various oral antimicrobial agents. Various epidemiological factors associated with ESBL for each patient were recorded on individual forms. This included age, presence of diabetes mellitus, renal calculi, pregnancy, history of urinary instrumentation, recurrent UTI and antibiotics intake. Results: Out of total of 140 strains of E. coli, which were screened for ESBL production, 30 (21.4%) isolates were positive. High-level resistance 94 (70%) was seen for many antimicrobial agents. Only4.5% of uropathogenic E. coli were resistant to Mecillinam. Various epidemiological factors associated with ESBL causing infections were female patients, H/o antimicrobial intake, elderly age > 60 years, renal calculi and H/o recurrent UTI. Conclusions: The epidemiology of ESBL positive uropathogenic E. coli is becoming more multifaceted. Nepal Journal of Medical Sciences | Volume 03 | Number 01 | January-June 2014 | Page 5-7 DOI: http://dx.doi.org/10.3126/njms.v3i1.10341

Isolation and Antibiotic Sensitivity Pattern of Extended Spectrum Beta Lactamases (ESBL) Producing Escherichia coli Isolated from Urinary Tract Infection

“…This is in correlation with other studies such as Mahesh et al, (2010) and Chaudhary et al, (2013) who reported 56.2% and 54.5% ESBL production in E. coli isolates respectively. However our findings are in contrast with other studies conducted by Datta et al, (2014) Dugal et al, (2013 DMBT Dissanayake et al, (2012) and Singh et al, (2016) who reported 21.4%, 24.4%, 29% and 82.6% ESBL producing E. coli isolates respectively.…”

Distribution of ExPEC Virulence Factors, blaCTX-M, fosA3, and mcr-1 in Escherichia coli Isolated From Commercialized Chicken Carcasses

“…ESBL-producing bacteria have been increasingly detected in meat from food-producing animals such as, poultry (Ghodousi et al, 2015; Shrestha et al, 2017; Poirel et al, 2018). Our findings have raised significant concerns, since the 30% prevalence of ESBL-producing samples in chicken carcasses in southern Brazil was higher than those reported in other regions, as in USA (27%), in India (21%) and in other samples from Brazil (7%) (Freeman et al, 2009; Datta et al, 2014; Gonçalves et al, 2016). Among all ESBL strains, we found 97% classified as bla CTX−M and the majority belonged to CTX-M-2 group, although the rates varied depending on the region worldwide.…”

Prevalence and antibiotic resistance pattern of extended spectrum beta lactamase producing Escherichia coli isolated from urinary tract infection

“…Out of 291, E. coli isolates, 108 (37.11%) are ESBL-producer and 183 (62.89%) are non-ESBL-producer. Other studies reported a prevalence of ESBL-producer E. coli isolates 46.87% (10), 82.6% (11) and 21.4% (12) respectively. This different results may be due to the difference in the risk factors include recent antibiotic therapy, administration of corticosteroids, hospitalization (13).…”