Community versus orthopaedic controls in traumatic brain injury research: How comparable are they?

Mathias, Jane L.; Dennington, V.; Bowden, Stephen C.; Bigler, Erin D.

doi:10.3109/02699052.2013.793398

Cited by 44 publications

(34 citation statements)

References 30 publications

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“…Therefore, the current sample comprised 162 people who had a TBI ( N mild = 133, N moderate = 15, N severe = 14) and 107 controls ( N healthy = 60, N orthopaedic = 47). The healthy and orthopaedic controls did not differ demographically (age: t (105) = −.488, p = .626; education: t (103) = .432, p = .667; proportion of males and females: X 2 (1) = 3.324, p = .068) or in terms of reaction times (compatible reaction time: t (101) = −.107, p = .915; incompatible reaction time: t (101) = −.526, p = .600) or fixel findings (see Supplementary figures); thus, all analyses were completed using a combined control group (Mathias, Dennington, Bowden, & Bigler, ; Wallace et al, ). The moderate and severe TBI groups were additionally combined for the subgroup analyses because they were too small to examine separately ( N moderate–severe = 29).…”

Section: Methodsmentioning

confidence: 86%

A fixel‐based analysis of micro‐ and macro‐structural changes to white matter following adult traumatic brain injury

Wallace

Mathias

Ward

et al. 2020

Human Brain Mapping

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Diffusion tensor imaging is often used to assess white matter (WM) changes following traumatic brain injury (TBI), but is limited in voxels that contain multiple fibre tracts.Fixel-based analysis (FBA) addresses this limitation by using a novel method of analysing high angular resolution diffusion-weighted imaging (HARDI) data. FBA examines three aspects of each fibre tract within a voxel: tissue micro-structure (fibre density [FD]), tissue macro-structure (fibre-bundle cross section [FC]) and a combined measure of both (FD and fibre-bundle cross section [FDC]). This study used FBA to identify the location and extent of micro-and macro-structural changes in WM following TBI. A large TBI sample (N mild = 133, N moderate-severe = 29) and control group (healthy and orthopaedic; N = 107) underwent magnetic resonance imaging with HARDI and completed reaction time tasks approximately 7 months after their injury (range:98-338 days). The TBI group showed micro-structural differences (lower FD) in the corpus callosum and forceps minor, compared to controls. Subgroup analyses revealed that the mild TBI group did not differ from controls on any fixel metric, but the moderate to severe TBI group had significantly lower FD, FC and FDC in multiple WM tracts, including the corpus callosum, cerebral peduncle, internal and external capsule. The moderate to severe TBI group also had significantly slower reaction times than controls, but the mild TBI group did not. Reaction time was not related to fixel findings.Thus, the WM damage caused by moderate to severe TBI manifested as fewer axons and a reduction in the cross-sectional area of key WM tracts. K E Y W O R D Sadults, diffusion-weighted imaging, fixel-based analysis, neuroimaging, traumatic brain injury

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Section: Methodsmentioning

confidence: 86%

A fixel‐based analysis of micro‐ and macro‐structural changes to white matter following adult traumatic brain injury

Wallace

Mathias

Ward

et al. 2020

Human Brain Mapping

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“…Finally, the current analyses did not include typically developing children as a control group even though they were recruited in the study. However, the OI constitute an appropriate comparison group and is even thought to provide more optimal control over general‐injury effects such as fatigue, stress, and pain (Mathias et al, ; McKinlay et al, ; Yeates, ). Additionally, previous work on the current cohort indicates that the two control groups may be more similar than expected as they had comparable demographic, developmental, cognitive and family functioning profiles (Beauchamp et al, ).…”

Section: Discussionmentioning

confidence: 99%

Developmental trajectories of adaptive functioning following early mild traumatic brain injury

Dégeilh

Bernier

Gravel

et al. 2018

Developmental Psychobiology

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Adaptive behavior impairments have been reported in children with severe traumatic brain injury (TBI) but are not typically found following mild TBI. It is possible that mild TBI induces subtle changes in adaptive functioning that are not captured in conventional group comparisons. This study aimed to explore time course changes in adaptive functioning following early mild TBI. Parents of 63 children with mild TBI and 53 children with orthopedic injuries aged between 1.5 and 5 years at the time of injury completed the Adaptive Behavior Assessment System‐II at three time points: retrospectively to assess pre‐injury functioning, then at 6 and 18 months post‐injury. Developmental trajectories of adaptive functioning domains (practical, conceptual, and social) reported by parents were modeled using linear mixed‐model analyses. Findings suggest that mild TBI may disrupt the expected developmental progression of children's social adaptive behavior, but does not appear to alter practical and conceptual domains.

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“…Orthopedic injured (OI) only groups have been a standard control group in many TBI studies as they are considered to share many of the same injury-related experiences including hospitalizations, pain and/or other medication use, and injury-related stress [46, 59]. For these reasons, we recruited an orthopedic injured (OI) only control that consisted of 59 (47 male, 12 female) Service Members identified through the Orthopedic Clinic at the same MTF.…”

Section: Methodsmentioning

confidence: 99%

“…There are a number of possible methodological (i.e., group analyses, sensitivity of gross volumetric measurements, different analysis tools) and even clinical (i.e., subtleness of the injury, unique spatial distributions of injury) reasons for the lack of reproducible findings. However, the increased sensitivity of shape analyses for detecting subtle differences in surfaces of subcortical structures as applied to other neurological disorders [35, 46, 70] may extend or improve the detection of differences between groups in volumetric studies of mTBI. Ultimately, these analyses may potentially prove more useful in detecting injury, predicting outcomes, evaluating long term structural change and plasticity, and/or evaluating therapeutic effects of interventions.…”

Section: Introductionmentioning

confidence: 99%

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

et al. 2016

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Mild traumatic brain injury (mTBI) is a significant health concern. The majority who sustain mTBI recover, although ~20 % continue to experience symptoms that can interfere with quality of life. Accordingly, there is a critical need to improve diagnosis, prognostic accuracy, and monitoring (recovery trajectory over time) of mTBI. Volumetric magnetic resonance imaging (MRI) has been successfully utilized to examine TBI. One promising improvement over standard volumetric approaches is to analyze high-dimensional shape characteristics of brain structures. In this study, subcortical shape and volume in 76 Service Members with mTBI was compared to 59 Service Members with orthopedic injury (OI) and 17 with post-traumatic stress disorder (PTSD) only. FreeSurfer was used to quantify structures from T1-weighted 3 T MRI data. Radial distance (RD) and Jacobian determinant (JD) were defined vertex-wise on parametric mesh-representations of subcortical structures. Linear regression was used to model associations between morphometry (volume and shape), TBI status, and time since injury (TSI) correcting for age, sex, intracranial volume, and level of education. Volumetric data was not significantly different between the groups. JD was significantly increased in the accumbens and caudate and significantly reduced in the thalamus of mTBI participants. Additional significant associations were noted between RD of the amygdala and TSI. Positive trendlevel associations between TSI and the amygdala and accumbens were observed, while a negative association was observed for third ventricle. Our findings may aid in the initial diagnosis of mTBI, provide biological targets for functional examination, and elucidate regions that may continue remodeling after injury.

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Community versus orthopaedic controls in traumatic brain injury research: How comparable are they?

Abstract: The current findings suggest that an orthopaedic injury control group does not have any clear advantages over a carefully recruited community control group.

Cited by 44 publications

References 30 publications

A fixel‐based analysis of micro‐ and macro‐structural changes to white matter following adult traumatic brain injury

A fixel‐based analysis of micro‐ and macro‐structural changes to white matter following adult traumatic brain injury

Developmental trajectories of adaptive functioning following early mild traumatic brain injury

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

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