Comorbid Behavioral Problems and Psychiatric Disorders in Autism Spectrum Disorders

Belardinelli, Cecilia; Raza, Mahreen

doi:10.4172/2472-1786.100011

Cited by 7 publications

(1 citation statement)

References 46 publications

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“…Indeed, the literature describes stress and restlessness as common among children with ASD [3,4]. Specifically, ADHD was found to be the most common condition comorbid to ASD [49]. Parents described associating cannabis intervention with calming effects, perceiving it as a potential answer to their children's restlessness.…”

Section: Adherencementioning

confidence: 99%

Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis

David,

Stolar,

Berkovitch

et al. 2024

Med Cannabis Cannabinoids

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IIntroduction. Medical cannabis treatment for autistic children has recently become popular, and studies have focused on examining the treatment’s effects on children’s symptom presentation, reported side effects, and dropout rates. However, no previous study has investigated the factors influencing adherence and dropout rates in cannabis treatment. Method. This explanatory sequential mixed-methods study explored these factors by examining the characteristics of 87 autistic children and their families and deepening parents’ perspectives and experiences of the 6-month CBD-rich cannabis treatment’s benefits and barriers. Results. We found this treatment to have a high (75%) adherence rate, relatively mild side effects, and substantial reported benefits for the children and families. However, this treatment was not free of barriers; the intake regime, some side effects, and in some cases, unrealistic parental expectations made adherence difficult for some families. Conclusion. Our results highlight the importance of providing professional guidance and knowledge to parents of autistic children, enhancing their understanding of the impact of CBD-rich cannabis treatment on their children and expected related challenges and coordinating realistic treatment expectations. We hope that addressing these important aspects will influence parents’ ability to adhere to and enjoy the benefits of cannabis treatment for their autistic children.

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Section: Adherencementioning

confidence: 99%

Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis

David,

Stolar,

Berkovitch

et al. 2024

Med Cannabis Cannabinoids

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Implications ofde novomutations in guiding drug discovery: A study of four neuropsychiatric disorders

Wong

2017

Preprint

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Recent studies have suggested an important role of de novo mutations (DNMs) in neuropsychiatric disorders. As DNMs are not subject to elimination due to evolutionary pressure, they are likely to have greater disruptions on biological functions. While a number of sequencing studies have been performed on neuropsychiatric disorders, the implications of DNMs for drug discovery remain to be explored.In this study, we employed a gene-set analysis approach to address this issue. Four neuropsychiatric disorders were studied, including schizophrenia (SCZ), autistic spectrum disorders (ASD), intellectual disability (ID) and epilepsy. We first identified gene-sets associated with different drugs, and analyzed whether the gene-set pertaining to each drug overlaps with DNMs more than expected by chance. We also assessed which medication classes are enriched among the prioritized drugs. We discovered that neuropsychiatric drug classes were indeed significantly enriched for DNMs of all four disorders; in particular, antipsychotics and antiepileptics were the most strongly enriched drug classes for SCZ and epilepsy respectively. Interestingly, we revealed enrichment of several unexpected drug classes, such as lipid-lowering agents for SCZ and anti-neoplastic agents. By inspecting individual hits, we also uncovered other interesting drug candidates or mechanisms (e.g. histone deacetylase inhibition and retinoid signaling) that might warrant further investigations.Taken together, this study provided evidence for the usefulness of DNMs in guiding drug discovery or repositioning.

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Analysis on the current condition of virtual reality and computer graphics and the applications on the digital media interaction

2016

2016 International Conference on Inventive Computation Technologies (ICICT)

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Comorbid Behavioral Problems and Psychiatric Disorders in Autism Spectrum Disorders

Cited by 7 publications

References 46 publications

Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis

Characteristics for Medical Cannabis Treatment Adherence among Autistic Children and Their Families: A Mixed-Methods Analysis

Implications ofde novomutations in guiding drug discovery: A study of four neuropsychiatric disorders

Analysis on the current condition of virtual reality and computer graphics and the applications on the digital media interaction

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