Comorbid depression in obstructive sleep apnea: an under-recognized association

BaHammam, Ahmed S.; Kendzerska, Tetyana; Gupta, Ravi; Ramasubramanian, Chellamuthu; Neubauer, David N.; Narasimhan, Meera; Pandi-Perumal, Seithikurippu R.; Moscovitch, Adam

doi:10.1007/s11325-015-1223-x

Cited by 103 publications

(79 citation statements)

References 68 publications

(75 reference statements)

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“…Unlike other studies using the SCL-90-R, we found that patients with great daytime sleepiness and cognitive complaints have increased values of anxiety, depression, obsession and interpersonal sensitivity symptoms (BaHammam et al, 2015). Actually, recent research refers that the OSAS can be associated with less vigour, diminished interest or pleasure, decreases in social contacts, poor compliance with treatments and less ability to perform cognitive tasks requiring alternative options, for instance, eating behaviour (Sforza, de Saint Hilaire, Pelissolo, Rochat, & Ibanez, 2002).…”

Section: Discussioncontrasting

confidence: 75%

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Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Ribeiro¹,

Carvalho²,

Carmo³

et al. 2017

RHS

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Section: Discussioncontrasting

confidence: 75%

“…The overlap of the OSAS and depression may also worsen the severity of the disease; the prevalence of depression in the OSAS's clinical populations varies widely from 7% to 63% (BaHammam et al, 2015;Douglas et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Ribeiro¹,

Carvalho²,

Carmo³

et al. 2017

RHS

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“…Obstructive sleep apnea (OSA) is more common in pregnancy,73 and OSA is associated with an increased risk of gestational hypertension, intrauterine growth retardation, and gestational diabetes mellitus 73. OSA is associated with major depression in the general population; longitudinal studies show an increased risk of developing major depression in patients with OSA, and severity of OSA is related to the risk of developing major depression 74. Continuous positive airway pressure (CPAP) has been found to improve symptoms of depression in OSA patients with comorbid depression in some but not all studies of major depression in non-pregnant patients 7576…”

Section: Personalized Treatment For Specific Clinical Characteristicsmentioning

confidence: 99%

Management of perinatal depression with non-drug interventions

Johansen

Robakis

Williams

et al. 2019

BMJ

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Perinatal depression is a common disorder that has been associated with serious risks to mother and child. Recently, screening for depression in pregnant and postpartum women has increased, as has the development of new psychotherapy and non-drug treatment modalities. Matching patients to treatments can be challenging, and although research into personalized treatment of major depression in the general population has increased, no published guidelines focus on personalized treatment approaches to perinatal depression. In particular, guidelines on non-drug treatments are lacking. This review summarizes the evidence on personalized non-drug treatment of perinatal depression, how to incorporate patients’ preferences, novel treatments under investigation, and the potential role of biomarkers in matching patients to treatment. The review provides recommendations for future research in personalized care of perinatal depression.

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“…(4) tarafından bildirilmiş olup takip eden yıllar boyunca pek çok çalışmada OUAS ile yaşam kalitesinde bozulma, depresyon ve mod değişiklikleri arasında pozitif bir ilişki olduğu gösterilmiştir (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Yapılan çalışmalarda OUAS'li hastalarda depresyon sıklığı %5-63 gibi değişen oranlarda bulunmuştur (11). Bu çalışmalar arasında depresyonun OUAS şiddeti ile ilişkili olduğunu tespit edenlerin yanı sıra hastalığın şiddetinden bağımsız olarak GAU gibi semptomlar ile ilişkili olduğunu gösterenler de mevcuttur.…”

Section: Introductionunclassified

“…Bu çalışmalar arasında depresyonun OUAS şiddeti ile ilişkili olduğunu tespit edenlerin yanı sıra hastalığın şiddetinden bağımsız olarak GAU gibi semptomlar ile ilişkili olduğunu gösterenler de mevcuttur. Bu tartışmalar bu konuda yapılmış ilk çalışmalardan günümüze kadar halen devam etmektedir (5,9,11,13). Çalışmalarda hastalardaki mod değişikliklerini tespit etmek için yaşam kalitesi ve depresyonu ölçen çeşitli skalalar kullanılmıştır.…”

Section: Introductionunclassified

Obstrüktif Uyku Apne Semptomları ile Uyku Laboratuvarına Başvuran Hastalarda Hastane Anksiyete Depresyon Skorlarının Semptomlar ve Polisomnografik Bulgular ile İlişkisi

Salepçi¹,

Güngör²,

Parmaksız³

et al. 2016

jtsm

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Objective: Several studies have investigated the association between obstructive sleep apnea syndrome (OSAS) and depression and anxiety; however, the relationship is still not understood very well. In this study we aimed to investigate the association between the hospital anxiety and depression (HAD) scores and the symptoms and polysomnographic (PSG) findings in patients referred with OSAS symptoms. Materials and Methods:Patients who referred with snoring, witnessed apnea and daytime sleepiness symptoms and patients who had full-night PSG were included in this study. Illiterate patients were not included in the study. Epworth sleepiness scale and HAD scores was self-administered by the patients. Patients were compared according to HAD scores for symptoms, comorbidities, and PSG findings. Also, the correlation between HAD and PSG findings, symptoms and Epworth scores (ES) of the patients were analyzed. Results: Out of 149 patients who included in the study mean age was 48±11, mean body mass index (BMI) was 31±5, and 63% were male. Of the patients 127 (85%) had OSAS. Of the patients 32 (21%) had a high likelihood of depression (DS >10) and 24 (16%) of anxiety (AS >10). ESS and asthma rate were significantly higher in DS >7 subjects compared to DS <7 (p=0.019, p=0.015, respectively). Minimum oxygen saturation (minSpO 2 ) in PSG was found significantly lower in AS >10 subjects compared to AS <10 subjects (p=0.005). There were no difference concerning other parameters (p>0.05). There were correlations between DS and age, female gender and mean oxygen saturation; AS and female gender, BMI, ES and excessive daytime sleepiness. Conclusion: We did not find any association between hospital anxiety depression score and presence of OSAS and apnea hypopnea index in our study. Excessive daytime sleepiness was found as the most important factor related to depression and anxiety scores in our patients. Keywords: Obstructive sleep apnea syndrome, hospital anxietydepression scale, excessive daytime sleepiness Amaç: Obstrüktif uyku apne sendromu (OUAS) ile depresyon ve anksiyete ilişkisi pek çok çalışmada gösterilmiş olmakla birlikte bu ilişki tam olarak anlaşılamamıştır. Çalışmamızda OUAS semptomları ile laboratuvarımıza refere edilen hastalarda hastane anksiyete depresyon (HAD) skorları ile semptomlar ve polisomnografi (PSG) bulguları arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya uyku laboratuvarına horlama, tanıklı apne ve gündüz aşırı uykululuk semptomları ile refere edilen, ilk gece PSG yapılan hastalar dahil edildi. Okuma yazması olmayan hastalar çalışmaya alınmadı. Tüm gece PSG yapıldıktan sonra ertesi sabah hastaların semptomları ve ek hastalıkları sorgulandı. Vücut kitle indeksleri (VKİ) hesaplandı. Epworth uykuluk skalası ve HAD skalası hastaların kendileri tarafından dolduruldu. Epworth, anksiyete ve depresyon skorları hesaplandı. Hastalar skorlarına göre kategorize edildi. HAD skorlarına göre semptomlar, ek hastalıklar ve PSG bulguları açısından karşılaştırıldı. Ayrıca HAD skorları ile semptomla...

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Comorbid depression in obstructive sleep apnea: an under-recognized association

Abstract: Depression is prevalent among patients with OSA both in the community and in sleep disorder clinics. Clinicians in general should be aware of this significant association and should aim to treat both disorders.

Cited by 103 publications

References 68 publications

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Management of perinatal depression with non-drug interventions

Obstrüktif Uyku Apne Semptomları ile Uyku Laboratuvarına Başvuran Hastalarda Hastane Anksiyete Depresyon Skorlarının Semptomlar ve Polisomnografik Bulgular ile İlişkisi

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